Protein Information

Name tyrosine hydroxylase
Synonyms Putative tyrosine hydroxylase variant; TH; TH protein; TYH; Truncated tyrosine hydroxylase; Tyrosine 3 hydroxylase; Tyrosine 3 monooxygenase; Tyrosine hydroxylase…

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
19406037 Naha N, Lee HY, Hwang JS, Bahk JY, Park MS, Lee SY, Kim SH, Kim MO: Nicotine tolerance to PC12 cell line: acute and chronic exposures modulate dopamine D2 receptor and tyrosine hydroxylase expression. Neurol Res. 2009 Apr;31(3):289-99.
243(3,3,3,3) Details
19476543 Radcliffe PM, Sterling CR, Tank AW: Induction of tyrosine hydroxylase mRNA by nicotine in rat midbrain is inhibited by mifepristone. J Neurochem. 2009 Jun;109(5):1272-84. Epub 2009 Mar 23.
38(0,1,2,3) Details
19594327 Singh S, Singh K, Patel DK, Singh C, Nath C, Singh VK, Singh RK, Singh MP: The expression of CYP2D22, an ortholog of human CYP2D6, in mouse striatum and its modulation in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease phenotype and nicotine-mediated neuroprotection. Rejuvenation Res. 2009 Jun;12(3):185-97.

Tyrosine hydroxylase (TH)-immunoreactivity in the substantia nigra, the expression of nicotinic acetylcholine receptors (nAChRs) alpha6 and alpha4, dopamine content, and 1-methyl-4-phenylpyridinium ion (MPP (+)) level in the striatum were measured to confirm the MPTP-induced PD phenotype and nicotine-mediated neuroprotection.
31(0,1,1,1) Details
19786030 Schemann M, Hafsi N, Michel K, Kober OI, Wollmann J, Li Q, Zeller F, Langer R, Lee K, Cellek S: The beta3-adrenoceptor agonist GW427353 (Solabegron) decreases excitability of human enteric neurons via release of somatostatin. Gastroenterology. 2010 Jan;138(1):266-74. Epub 2009 Sep 25.

Tissue perfusion with GW427353 reduced nicotine-evoked neuronal spike frequency, an effect prevented by the beta3-AR antagonist SR-59230 and the SST2-receptor antagonist CYN154806 and mimicked by the SST2 receptor agonist octreotide.
Immunohistochemistry was used to detect adiponectin, beta3-AR, SST, SST2 receptors, tyrosine hydroxylase (TH), and protein gene product 9.5.
1(0,0,0,1) Details
20190011 Oliveira E, Pinheiro C, Santos-Silva A, Trevenzoli I, Abreu-Villaca Y, Nogueira Neto J, Reis A, Passos M, Moura E, Lisboa P: Nicotine exposure affects mother's and pup's nutritional, biochemical and hormonal profiles during lactation in rats. J Endocrinol. 2010 Feb 26.

The 15 days-old NIC-pups presented higher total body fat, higher HDL-cholesterol, serum leptin, serum corticosterone and adrenal catecholamine content, but lower tyrosine hydroxylase protein levels.
1(0,0,0,1) Details
19685015 Quik M, Campos C, Parameswaran N, Langston JW, McIntosh JM, Yeluashvili M: Chronic nicotine treatment increases nAChRs and microglial expression in monkey substantia nigra after nigrostriatal damage. J Mol Neurosci. 2010 Jan;40(1-2):105-13. Epub 2009 Aug 15.

0(0,0,0,0) Details