| Name | norepinephrine transporters |
|---|---|
| Synonyms | NAT1; NAT1; NET1; NET; Norepinephrine transporter; Norepinephrine transporter protein 1; SLC6A2; SLC6A5… |
| Name | nicotine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 20078461 | Sofuoglu M: Cognitive enhancement as a pharmacotherapy target for stimulant addiction. Addiction. 2010 Jan;105(1):38-48. These include galantamine, and rivastigmine (cholinesterase inhibitors), varenicline (partial nicotine agonist), guanfacine (alpha (2)-adrenergic agonist) and atomoxetine (norepinephrine transporter inhibitor). |
31(0,1,1,1) | Details |
| 19821577 | Carroll FI, Blough BE, Abraham P, Mills AC, Holleman JA, Wolckenhauer SA, Decker AM, Landavazo A, McElroy KT, Navarro HA, Gatch MB, Forster MJ: Synthesis and biological evaluation of analogues as potential pharmacotherapies for cocaine addiction. J Med Chem. 2009 Nov 12;52(21):6768-81. Their in vitro pharmacological properties were examined by [(3) H] ([(3) H] DA), [(3) H] ([(3) H] 5HT), and [(3) H] ([(3) H] NE) uptake inhibition studies, and by binding studies at the and norepinephrine transporters using [(125) I] RTI-55 in cloned transporters. Twenty-four analogues were evaluated for generalization to cocaine drug discrimination after i.p. administration, and twelve analogues were tested in a time course cocaine discrimination study using oral administration. 2-(N-Cyclopropylamino)-3-chloropropiophenone (1x) had the most favorable in vitro efficacy and in vivo pharmacological profile for an indirect agonist pharmacotherapy for treating cocaine, methamphetamine, nicotine, and other drugs of abuse addiction. |
1(0,0,0,1) | Details |
| 20346966 | Paterson NE, Fedolak A, Olivier B, Hanania T, Ghavami A, Caldarone B: Psychostimulant-like discriminative stimulus and locomotor sensitization properties of the wake-promoting agent modafinil in rodents. Pharmacol Biochem Behav. 2010 Mar 24. In contrast, repeated administration of modafinil resulted in the expression, but not induction, of LS. d-amphetamine, but not the mu-opioid agonist morphine or the nAChR agonist nicotine, fully substituted for the cocaine DS in rats. |
0(0,0,0,0) | Details |