Protein Information

Name CA3
Synonyms CA III; Carbonic anhydrase C; CA3; CAIII; Car3; Carbonate dehydratase III; Carbonic anhydrase 3; Carbonic anhydrase III…

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
20138127 Oliveira-da-Silva A, Manhaes AC, Cristina-Rodrigues F, Filgueiras CC, Abreu-Villaca Y: Hippocampal increased cell death and decreased cell density elicited by nicotine and/or ethanol during adolescence are reversed during drug withdrawal. Neuroscience. 2010 Apr 28;167(1):163-73. Epub 2010 Feb 4.

In the present study, we investigated the effects of adolescent nicotine and/or ethanol withdrawal on the following regions of the hippocampus: Granular layer of the Dentate Gyrus (GrDG), Molecular layer (Mol), CA1, CA2 and CA3.
6(0,0,1,1) Details
19693709 Grybko M, Sharma G, Vijayaraghavan S: Functional distribution of nicotinic receptors in CA3 region of the hippocampus. J Mol Neurosci. 2010 Jan;40(1-2):114-20. Epub 2009 Aug 20.

It is likely that effects of nicotine are due to its ability to modulate network excitability as a whole.
4(0,0,0,4) Details
19410565 Son JH, Winzer-Serhan UH: Chronic neonatal nicotine exposure increases mRNA expression of neurotrophic factors in the postnatal rat hippocampus. Brain Res. 2009 Jun 30;1278:1-14. Epub 2009 May 3.

Specifically, BDNF mRNA expression, detected in CA1, CA3 stratum (s.) pyramidal and granule cell layer of the dentate gyrus (DG), was increased by 27.4%, 23.26% and 27.3%, respectively.
3(0,0,0,3) Details
20153739 Hunter RG, Bloss EB, McCarthy KJ, McEwen BS: Regulation of the nicotinic receptor alpha7 subunit by chronic stress and corticosteroids. Brain Res. 2010 Feb 11.

The alpha7 subunit of the nicotinic acetylcholine receptor (NAchRalpha7) is one of the principal brain receptors for nicotine and is thought to be a mediator of nicotine's pro-cognitive effects.
We found that CRS increased the levels of NAchRalpha7 mRNA in the CA1, CA3 and dentate gyrus while levels of the protein were lowered by the same treatment.
1(0,0,0,1) Details
19457080 Bancila V, Cordeiro JM, Bloc A, Dunant Y: Nicotine-induced and depolarisation-induced glutamate release from hippocampus mossy fibre synaptosomes: two distinct mechanisms. J Neurochem. 2009 Jul;110(2):570-80. Epub 2009 May 15.

Hippocampus mossy fibre terminals activate CA3 pyramidal neurons via two distinct mechanisms, both quantal and glutamatergic: (i) rapid excitatory transmission in response to afferent action potentials and (ii) delayed and prolonged release following nicotinic receptor activation.
1(0,0,0,1) Details
20105181 Huang LT, Sherwood JL, Sun YJ, Lodge D, Wang Y: Activation of presynaptic alpha7 nicotinic receptors evokes an excitatory response in hippocampal CA3 neurones in anaesthetized rats: an in vivo iontophoretic study. Br J Pharmacol. 2010 Jan 26.

Furthermore, iontophoretic application of nicotine, AR-R17779 and PSAB-OFP each evoked current-dependent excitation of most CA3 pyramidal neurones studied, and this excitation was antagonized by co-iontophoretic application of MLA.
34(0,1,1,4) Details
20004706 Lu CB, Henderson Z: Nicotine induction of theta frequency oscillations in rodent hippocampus in vitro. Neuroscience. 2010 Mar 10;166(1):84-93. Epub 2009 Dec 23.

Bath-application of a low concentration of nicotine (1 muM) to transversely-cut hippocampal slices produced persistent theta-frequency oscillations in area CA3 of the hippocampus.
7(0,0,1,2) Details
19777383 Dunant Y, Bancila V, Cordeiro M: Ultra-fast versus sustained cholinergic transmission: a variety of different mechanisms. J Mol Neurosci. 2010 Jan;40(1-2):27-31.

In the present work, we compare two examples of ultra-rapid transmission (the Torpedo nerve electroplaque synapse and the rat hippocampus mossy fiber/CA3 synapses), with a cholinergic process operating with high affinity but at a low speed: the release of glutamate elicited by nicotine from mossy fibers of the rat hippocampus.
31(0,1,1,1) Details
19576279 Oliveira-da-Silva A, Vieira FB, Cristina-Rodrigues F, Filgueiras CC, Manhaes AC, Abreu-Villaca Y: Increased apoptosis and reduced neuronal and glial densities in the hippocampus due to nicotine and ethanol exposure in adolescent mice. Int J Dev Neurosci. 2009 Oct;27(6):539-48. Epub 2009 Jul 1.

Considering the role of the hippocampus in both anxiety and memory/learning, we investigated whether adolescent nicotine and/or ethanol administration elicit apoptotic cell death and whether this results in neuronal and/or glial density alterations in the following regions of the hippocampus: granular layer of the dentate gyrus (GrDG), molecular layer (Mol), CA1, CA2 and CA3.
6(0,0,1,1) Details