Protein Information

Name NFkappaB (protein family or complex)
Synonyms NF kappa B; NFKB; NFkappaB; Nuclear factor NF kappa B

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
19147120 Nakao S, Ogata Y, Sugiya H: Nicotine stimulates the expression of cyclooxygenase-2 mRNA via NFkappaB activation in human gingival fibroblasts. Arch Oral Biol. 2009 Mar;54(3):251-7. Epub 2009 Jan 14.

Nicotine stimulation of IkappaBalpha, an inhibitor of NFkappaB degradation, was also characterized by Western blotting.
255(2,5,5,5) Details
19732285 Hosur V, Leppanen S, Abutaha A, Loring RH: Gene regulation of alpha4beta2 nicotinic receptors: microarray analysis of nicotine-induced receptor up-regulation and anti-inflammatory effects. J Neurochem. 2009 Nov;111(3):848-58. Epub 2009 Sep 1.

Nicotine suppresses IL-1beta and IL-6 expression at least in part by inhibiting NFkappaB activation.
31(0,1,1,1) Details