Protein Information

Name intercellular adhesion molecule 1
Synonyms BB2; CD54; CD54 antigen; ICAM 1; ICAM1; Intercellular adhesion molecule 1; Intercellular adhesion molecule 1 precursor; Major group rhinovirus receptor…

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
20079464 Zhou Y, Wang ZX, Tang MP, Yao CJ, Xu WJ, Wang LY, Qiao ZD: Nicotine induces cyclooxygenase-2 and prostaglandin E (2) expression in human umbilical vein endothelial cells. Int Immunopharmacol. 2010 Apr;10(4):461-6. Epub 2010 Jan 14.

In order to explain the mechanism of nicotine-induced endothelium dysfunction, we investigated the effects of nicotine on cyclooxygenase-2 (COX-2) and intercellular adhesion molecule-1 (ICAM-1) expression in human umbilical vein endothelial cells (HUVECs).
93(0,3,3,3) Details
20162355 Breen LT, McHugh PE, Murphy BP: HUVEC ICAM-1 and VCAM-1 Synthesis in Response to Potentially Athero-Prone and Athero-Protective Mechanical and Nicotine Chemical Stimuli. Ann Biomed Eng. 2010 May;38(5):1880-92. Epub 2010 Feb 17.
39(0,1,2,4) Details
19741199 Chatterjee PK, Al-Abed Y, Sherry B, Metz CN: Cholinergic agonists regulate JAK2/STAT3 signaling to suppress endothelial cell activation. Am J Physiol Cell Physiol. 2009 Nov;297(5):C1294-306. Epub 2009 Sep 9.

Treatment of macrovascular human umbilical vein endothelial cells (HUVECs) and microvascular endothelial cells (MVECs) with the cholinergic agonists nicotine and GTS-21 significantly reduced IL-6-mediated monocyte chemoattractant protein-1 (MCP-1) production and ICAM-1 expression which are regulated through the JAK2/STAT3 pathway.
31(0,1,1,1) Details
20050989 Rodella LF, Filippini F, Bonomini F, Bresciani R, Reiter RJ, Rezzani R: Beneficial effects of melatonin on nicotine-induced vasculopathy. J Pineal Res. 2009 Dec 30.

We evaluated the hydroxyproline content, and the different expression of proteins involved in several types of stress (ERK1/2), in fibrosis (TGF-beta1, NF-kappaB) and in recruitment of circulating leukocytes onto the vessel wall, including intercellular adhesion molecule-1 (ICAM-1) and vascular cellular adhesion molecule-1 (VCAM-1).
2(0,0,0,2) Details
19955489 Takahashi HK, Liu K, Wake H, Mori S, Zhang J, Liu R, Yoshino T, Nishibori M: Effect of nicotine on advanced glycation end product-induced immune response in human monocytes. J Pharmacol Exp Ther. 2010 Mar;332(3):1013-21. Epub 2009 Dec 2.

Among various subtypes of AGEs, glyceraldehyde-derived AGE (AGE-2) and glycolaldehyde-derived AGE (AGE-3) induce the expressions of intercellular adhesion molecule-1, B7.1, B7.2, and CD40 on monocytes, the production of interferon-gamma and tumor necrosis factor-alpha, and the lymphocyte proliferation in human peripheral blood mononuclear cells.
1(0,0,0,1) Details