Protein Information

Name myeloperoxidase
Synonyms 38 kDa MYELOPEROXIDASE; MPO; Myeloperoxidase; Myeloperoxidase precursor; Peroxidase (Myeloperoxidase); Myeloperoxidases; Myeloperoxidase precursors; Peroxidase (Myeloperoxidase)s

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
19769960 Kar Mahapatra S, Chakraborty SP, Majumdar S, Bag BG, Roy S: Eugenol protects nicotine-induced superoxide mediated oxidative damage in murine peritoneal macrophages in vitro. Eur J Pharmacol. 2009 Nov 25;623(1-3):132-40. Epub 2009 Sep 19.

There was a significant increase in the level of radical generation, NADPH oxidase and myeloperoxidase activity, lipid, protein, DNA damage and oxidized glutathione level in nicotine-treated group, which were significantly reduced by eugenol and N-acetylcysteine supplementation.
31(0,1,1,1) Details
19017736 Rudolph TK, Rudolph V, Baldus S: Contribution of myeloperoxidase to smoking-dependent vascular inflammation. Proc Am Thorac Soc. 2008 Dec 1;5(8):820-3.

Being stimulated by nicotine, neutrophils generate reactive oxygen species and release prooxidant enzymes like myeloperoxidase, which are capable of entering the vessel wall independently.
7(0,0,1,2) Details
19042965 Gunes T, Koklu E, Gunes I, Narin F, Koklu S: Influence of maternal nicotine exposure on neonatal rat oxidant-antioxidant system and effect of ascorbic acid supplementation. Hum Exp Toxicol. 2008 Oct;27(10):781-6.

Serum malondialdehyde (MDA), myeloperoxidase (MPO), and superoxide dismutase (SOD) levels were determined at 21 days of age.
1(0,0,0,1) Details