| Name | cyclin D1 |
|---|---|
| Synonyms | B cell CLL/lymphoma 1; B cell leukemia 1; BCL 1; BCL 1 oncogene; BCL1; CCND 1; CCND1; Cyclin D1… |
| Name | nicotine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 20106947 | Chen RJ, Ho YS, Guo HR, Wang YJ: Long-term Nicotine Exposure-Induced Chemoresistance is Mediated by Activation of Stat3 and Downregulation of ERK1/2 via nAChR and beta-AR in Human Bladder Cancer Cells. Toxicol Sci. 2010 Jan 27. We provide evidence for the first time that nicotine strongly activated Stat3 leading to Cyclin D1 overexpression, cell cycle perturbations, and chemoresistance. |
81(1,1,1,1) | Details |
| 20229177 | Chen CS, Lee CH, Hsieh CD, Ho CT, Pan MH, Huang CS, Tu SH, Wang YJ, Chen LC, Chang YJ, Wei PL, Yang YY, Wu CH, Ho YS: Nicotine-induced human breast cancer cell proliferation attenuated by garcinol through down-regulation of the nicotinic receptor and cyclin D3 proteins. Breast Cancer Res Treat. 2010 Mar 13. Previous studies have demonstrated that the persistent exposure of human bronchial epithelial cells to nicotine (Nic) through nicotinic acetylcholine receptors increases cyclin D1 promoter activity and protein expression. |
6(0,0,1,1) | Details |
| 20061081 | Shin VY, Jin HC, Ng EK, Sung JJ, Chu KM, Cho CH: Activation of 5-lipoxygenase is required for nicotine mediated epithelial-mesenchymal transition and tumor cell growth. Cancer Lett. 2010 Jan 8. Blockade of 5-LOX signaling resulted in downregulation of cyclin D1, matrix metalloproteinase (MMP-7, -9), urokinase plasminogen activator (uPA) and its receptor (uPAR), and pro-apoptotic proteins. |
1(0,0,0,1) | Details |