Protein Information

Name task 3
Synonyms Acid sensitive potassium channel protein TASK 3; KCNK 9; KCNK9; KT3.2; Potassium channel TASK3; Potassium channel subfamily K member 9; TASK 3; TASK3…

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
19730368 Tsutsui-Kimura I, Ohmura Y, Izumi T, Yamaguchi T, Yoshida T, Yoshioka M: The effects of serotonin and/or noradrenaline reuptake inhibitors on impulsive-like action assessed by the three-choice serial reaction time task: a simple and valid model of impulsive action using rats. Behav Pharmacol. 2009 Sep;20(5-6):474-83.

The aims of this study were (i) to evaluate whether the three-choice serial reaction time task (3-CSRTT), a simple version of the five-choice serial reaction time task (5-CSRTT), is appropriate for brief assessment of impulsive-like action and (ii) to examine the effects of fluvoxamine, a selective serotonin reuptake inhibitor, and milnacipran, a serotonin/noradrenaline reuptake inhibitor, on impulsive-like action using the 3-CSRTT.
After training in the 3-CSRTT, rats were administered nicotine (0, 0.1, 0.2, and 0.4 mg/kg, salt, subcutaneously), atomoxetine [0, 0.01, 0.1, and, 1.0 mg/kg, intraperitoneally (i.p.)], fluvoxamine (0, 2, 4, and 8 mg/kg, i.p.), or milnacipran (0, 3, and 10 mg/kg, i.p.).
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20238211 Tsutsui-Kimura I, Ohmura Y, Izumi T, Yamaguchi T, Yoshida T, Yoshioka M: Nicotine provokes impulsive-like action by stimulating alpha4beta2 nicotinic acetylcholine receptors in the infralimbic, but not in the prelimbic cortex. Psychopharmacology. 2010 Mar 19.

OBJECTIVES: Our goal was to determine whether alpha4beta2 nAChRs in the prelimbic cortex (PL) and/or infralimbic cortex (IL), which are subregions of the mPFC, mediate nicotine-induced impulsive-like action in the three-choice serial reaction time task (3-CSRTT).
31(0,1,1,1) Details
19749485 Ohmura Y, Tsutsui-Kimura I, Yoshioka M: Assessment of attentional function and impulsivity using 5-choice serial reaction time task/3-choice serial reaction time task. Nippon Yakurigaku Zasshi. 2009 Sep;134(3):137-41.

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20217051 Perkins KA, Karelitz JL, Giedgowd GE, Conklin CA, Sayette MA: Differences in negative mood-induced smoking reinforcement due to distress tolerance, anxiety sensitivity, and depression history. Psychopharmacology. 2010 Mar 10.


METHODS: Adult smokers (N = 71) without current depression were randomly assigned to one of two smoking conditions (nicotine or denic cigarettes, presented blind) maintained across all sessions.
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20132927 Perkins KA, Karelitz JL, Conklin CA, Sayette MA, Giedgowd GE: Acute Negative Affect Relief from Smoking Depends on the Affect Situation and Measure but Not on Nicotine. Biol Psychiatry. 2010 Feb 2.

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