| Name | hcrtR1 |
|---|---|
| Synonyms | HCRTR 1; HCRTR1; Hypocretin receptor 1; Hypocretin receptor type 1; OX1R; Orexin 1 receptor; Orexin A receptor; Orexin receptor type 1… |
| Name | nicotine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 20177882 | LeSage MG, Perry JL, Kotz CM, Shelley D, Corrigall WA: Nicotine self-administration in the rat: effects of hypocretin antagonists and changes in hypocretin mRNA. Psychopharmacology. 2010 Apr;209(2):203-12. Epub 2010 Feb 24. CONCLUSIONS: These data confirm a previous report (Hollander et al., Proc Natl Acad Sci U S A 105:19480-19485, 2008) that the hypocretin receptor hcrtR1 is activated in nicotine reinforcement and in addition show that both the arcuate nucleus and lateral hypothalamus are sites at which hcrt receptor mechanisms may influence reinforcement. |
85(1,1,1,5) | Details |
| 20147556 | Plaza-Zabala A, Martin-Garcia E, de Lecea L, Maldonado R, Berrendero F: Hypocretins regulate the anxiogenic-like effects of nicotine and induce reinstatement of nicotine-seeking behavior. J Neurosci. 2010 Feb 10;30(6):2300-10. Pretreatment with the hypocretin receptor 1 (Hcrtr-1) antagonist SB334867 or preprohypocretin gene deletion blocked both nicotine effects. |
82(1,1,1,2) | Details |
| 19596018 | Winrow CJ, Tanis KQ, Reiss DR, Rigby AM, Uslaner JM, Uebele VN, Doran SM, Fox SV, Garson SL, Gotter AL, Levine DM, Roecker AJ, Coleman PJ, Koblan KS, Renger JJ: Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposure. Neuropharmacology. 2010 Jan;58(1):185-94. Epub 2009 Jul 14. Two receptors respond to orexin signaling, Orexin 1 Receptor (OX1R) and Orexin 2 Receptor (OX2R) with partially overlapping brain distributions. Further, DORA attenuates the ability of nicotine to induce reinstatement of extinguished responding for a reinforcer, demonstrating selectivity of the effect to reward pathways and not to food intake. |
2(0,0,0,2) | Details |
| 19033203 | Hollander JA, Lu Q, Cameron MD, Kamenecka TM, Kenny PJ: Insular hypocretin transmission regulates nicotine reward. Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19480-5. Epub 2008 Nov 24. Here we show that blockade of hypocretin transmission at hypocretin-1 (Hcrt-1; orexin-1) receptors decreases i.v. nicotine self-administration in rats and the motivation to obtain the drug. |
31(0,1,1,1) | Details |