Protein Information

Name beta adrenergic receptors (protein family or complex)
Synonyms Beta adrenoceptor; Beta adrenoceptor; Beta adrenergic receptor; Beta adrenergic receptors; Beta adrenoceptor; Beta adrenoceptors; Beta adrenoceptors

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
20106947 Chen RJ, Ho YS, Guo HR, Wang YJ: Long-term Nicotine Exposure-Induced Chemoresistance is Mediated by Activation of Stat3 and Downregulation of ERK1/2 via nAChR and beta-AR in Human Bladder Cancer Cells. Toxicol Sci. 2010 Jan 27.

Furthermore, nicotine mobilized Stat3 signaling, resulting in the loss of ERK1/2 activation and reduced chemosensitivity via nicotinic acetylcholine receptors and beta-adrenoceptors.
31(0,1,1,1) Details
19387337 Al-Wadei HA, Al-Wadei MH, Schuller HM: Prevention of pancreatic cancer by the beta-blocker propranolol. . Anticancer Drugs. 2009 Jul;20(6):477-82.

We have previously reported that beta-adrenergic receptors (beta-ARs) stimulate the proliferation and migration of human PDAC cells in vitro by cAMP-dependent signaling and that the nicotine-derived nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) activates this pathway directly in vitro while additionally stimulating the release of noradrenaline/adrenaline by binding to alpha7 nicotinic acetylcholine receptors (alpha7 nAChR) in hamsters.
31(0,1,1,1) Details
19785998 Gaede AH, Lung MS, Pilowsky PM: Catestatin attenuates the effects of intrathecal nicotine and isoproterenol. Brain Res. 2009 Dec 11;1305:86-95. Epub 2009 Sep 26.

The results indicate that Cts antagonizes both central nicotinic acetylcholine receptors and beta-adrenoceptors that are involved in cardiovascular regulation in vivo.
1(0,0,0,1) Details