Protein Information

Name tyrosine kinase receptors
Synonyms 55 kd protein; MTC; High affinity nerve growth factor receptor; High affinity nerve growth factor receptor precursor; NTRK 1; NTRK1; Neurotrophic tyrosine kinase receptor type 1; Oncogene tyrosine protein kinase receptor…

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
19824047 Urrego F, Scuri M, Auais A, Mohtasham L, Piedimonte G: Combined effects of chronic nicotine and acute virus exposure on neurotrophin expression in rat lung. Pediatr Pulmonol. 2009 Nov;44(11):1075-84.

Expression of the neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor, of their high-affinity tyrosine kinase receptors (trkA and trkB, respectively), and of the low-affinity receptor p75 (NTR) was measured in the lungs of nicotine-exposed rats both at the mRNA level by reverse-transcription polymerase chain reaction and at the protein level by enzyme-linked immunoassay.
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19305373 De Luca L, De Angelis C, Fagoonee S, Di Bella S, Rizzetto M, Pellicano R: Is smoking a prognostic factor in patients with chronic hepatitis C? . Minerva Gastroenterol Dietol. 2009 Jun;55(2):139-43.

Nicotine is mainly metabolised by the liver, and its administration in experimental animals showed development of steatosis and focal or confluent hepatic necrosis, probably linked to the oxidative stress associated with lipid peroxidation.
In chronic hepatitis C patients, preliminary studies have suggested that hypoxia caused by smoking may induce expression of the cytokines vascular endothelial growth factor (VEGF) and VEGF-D and their corresponding soluble tyrosine kinase receptors fms-like tyrosine kinase receptor and kinase insert domain receptor.
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20056136 Formaggio E, Fazzini F, Dalfini AC, Di Chio M, Cantu C, Decimo I, Fiorini Z, Fumagalli G, Chiamulera C: Nicotine increases the expression of neurotrophin receptor tyrosine kinase receptor A in basal forebrain cholinergic neurons. Neuroscience. 2010 Mar 17;166(2):580-9. Epub 2010 Jan 4.

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