| Name | ERK1 |
|---|---|
| Synonyms | ERK 1; ERK1; ERT 2; ERT2; Extracellular signal regulated kinase 1; Extracellular signal related kinase 1b; Extracellular signal related kinase 1c; HS44KDAP… |
| Name | nicotine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 20106947 | Chen RJ, Ho YS, Guo HR, Wang YJ: Long-term Nicotine Exposure-Induced Chemoresistance is Mediated by Activation of Stat3 and Downregulation of ERK1/2 via nAChR and beta-AR in Human Bladder Cancer Cells. Toxicol Sci. 2010 Jan 27. |
112(1,2,2,2) | Details |
| 19131543 | Al-Wadei HA, Plummer HK 3rd, Schuller HM: Nicotine stimulates pancreatic cancer xenografts by systemic increase in stress neurotransmitters and suppression of the inhibitory neurotransmitter Carcinogenesis. 2009 Mar;30(3):506-11. Epub 2009 Jan 8. Nicotine significantly increased the systemic levels of and cAMP while increasing xenograft size and protein levels of cAMP, cyclic AMP response element-binding protein and p-extracellular signal-regulated kinase 1/2 in the tumor tissue. |
81(1,1,1,1) | Details |
| 19358273 | Chipitsyna G, Gong Q, Anandanadesan R, Alnajar A, Batra SK, Wittel UA, Cullen DM, Akhter MP, Denhardt DT, Yeo CJ, Arafat HA: Induction of osteopontin expression by nicotine and cigarette smoke in the pancreas and pancreatic ductal adenocarcinoma cells. Int J Cancer. 2009 Jul 15;125(2):276-85. Inhibition of ERK1/2 activation reduced the nicotine-induced OPN synthesis. |
81(1,1,1,1) | Details |
| 19903766 | Zhao J, Xin M, Wang T, Zhang Y, Deng X: Nicotine enhances the antiapoptotic function of Mcl-1 through phosphorylation. Mol Cancer Res. 2009 Dec;7(12):1954-61. Epub 2009 Nov 10. Here, we found that nicotine induces Mcl-1 phosphorylation through activation of extracellular signal-regulated kinase 1/2 in association with increased chemoresistance of human lung cancer cells. |
81(1,1,1,1) | Details |
| 20211606 | Gubbins EJ, Gopalakrishnan M, Li J: alpha7 nAChR-mediated activation of MAP kinase pathways in PC12 cells. Brain Res. 2010 Mar 6. Robust concentration-dependent increase in ERK1/2 phosphorylation was triggered by structurally diverse alpha7 nAChR agonists such as nicotine, GTS-21, SSR-180711A and PNU-282987 in the presence of the positive allosteric modulator (PAM) PNU-120596. |
34(0,1,1,4) | Details |
| 19139119 | Sun X, Ritzenthaler JD, Zheng Y, Roman J, Han S: inhibits alpha4 nicotinic acetylcholine receptor expression in human lung carcinoma cells through peroxisome proliferator-activated receptor gamma-independent signals. Mol Cancer Ther. 2009 Jan;8(1):110-8. We and others have shown previously that nicotine, a major component of tobacco, stimulates non-small cell lung carcinoma (NSCLC) proliferation through nicotinic acetylcholine receptor (nAChR)-mediated signals. The inhibitory effect of on alpha4 nAChR expression was accompanied by phosphorylation of p38 mitogen-activated protein kinase and extracellular signal-regulated kinase 1/2 and down-regulation of Akt phosphorylation. |
1(0,0,0,1) | Details |
| 20050989 | Rodella LF, Filippini F, Bonomini F, Bresciani R, Reiter RJ, Rezzani R: Beneficial effects of on nicotine-induced vasculopathy. J Pineal Res. 2009 Dec 30. We evaluated the content, and the different expression of proteins involved in several types of stress (ERK1/2), in fibrosis (TGF-beta1, NF-kappaB) and in recruitment of circulating leukocytes onto the vessel wall, including intercellular adhesion molecule-1 (ICAM-1) and vascular cellular adhesion molecule-1 (VCAM-1). |
1(0,0,0,1) | Details |
| 19274673 | Al-Wadei HA, Schuller HM: Nicotinic receptor-associated modulation of stimulatory and inhibitory neurotransmitters in NNK-induced adenocarcinoma of the lungs and pancreas. J Pathol. 2009 Aug;218(4):437-45. The nicotine-derived nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1- (NNK) is a potent mutagen and the most powerful tobacco carcinogen. In contrast, protein expression of the alpha (7) nAChR, alpha (4) nAChR as well as p-CREB and p-ERK1/2 were up-regulated. |
1(0,0,0,1) | Details |
| 19387337 | Al-Wadei HA, Al-Wadei MH, Schuller HM: Prevention of pancreatic cancer by the beta-blocker . Anticancer Drugs. 2009 Jul;20(6):477-82. We have previously reported that beta-adrenergic receptors (beta-ARs) stimulate the proliferation and migration of human PDAC cells in vitro by cAMP-dependent signaling and that the nicotine-derived nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1- (NNK) activates this pathway directly in vitro while additionally stimulating the release of / by binding to alpha7 nicotinic acetylcholine receptors (alpha7 nAChR) in hamsters. |
0(0,0,0,0) | Details |
| 20113502 | Xu Y, Zhang Y, Cardell LO: Nicotine enhances murine airway contractile responses to kinin receptor agonists via activation of JNK- and PDE4-related intracellular pathways. Respir Res. 2010 Jan 29;11:13. |
0(0,0,0,0) | Details |