| Name | adenylyl cyclase |
|---|---|
| Synonyms | ADCY 7; ATP pyrophosphate lyase; Adenylyl cyclase; ADCY7; ADCY7 protein; ATP pyrophosphate lyase 7; Adenylate cyclase 7; Adenylate cyclase type 7… |
| Name | nicotine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19131543 | Al-Wadei HA, Plummer HK 3rd, Schuller HM: Nicotine stimulates pancreatic cancer xenografts by systemic increase in stress neurotransmitters and suppression of the inhibitory neurotransmitter Carcinogenesis. 2009 Mar;30(3):506-11. Epub 2009 Jan 8. In the current study, we have tested the hypothesis that nicotine stimulates the growth of PDAC xenografts in nude mice by increasing the systemic levels of the stress neurotransmitters and which are the physiological agonists for beta-adrenoreceptors and that inhibition by of the adenylyl cyclase-dependent pathway downstream of adrenoreceptors blocks this effect. |
31(0,1,1,1) | Details |
| 19806344 | McCarthy MJ, Zhang H, Neff NH, Hadjiconstantinou M: Nicotine withdrawal and kappa-opioid receptors. . Psychopharmacology. 2009 Oct 6. RATIONALE: The synthesis and release of dynorphin are increased in the caudate/putamen (CPU) and nucleus accumbens (NAc) of nicotine-withdrawn mice, suggesting a role in the nicotine abstinence syndrome. KOPr coupling and function were investigated by agonist (U69-593)-stimulated [(35) S] GTPgammaS binding autoradiography and inhibition of adenylyl cyclase activity. |
2(0,0,0,2) | Details |
| 20146581 | Schuller HM, Al-Wadei HA: Neurotransmitter receptors as central regulators of pancreatic cancer. . Future Oncol. 2010 Feb;6(2):221-8. Experimental evidence indicates that the alpha (7)-nicotinic acetylcholine receptor (alpha (7) nAChR) stimulates PDAC via stress neurotransmitter-mediated activation of beta-adrenergic signaling while the alpha (4) beta (2) nAChR inhibits PDAC via -mediated inhibition of adenylyl cyclase activation. In analogy to molecular mechanisms that govern nicotine addiction, chronic exposure to nicotine or its nitrosated derivative nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1- render the stimulatory alpha (7) nAChR hyperactive while desensitizing the inhibitory alpha (4) beta (2) nAChR. |
1(0,0,0,1) | Details |