Protein Information

Name apolipoprotein E
Synonyms AD2; APOE; Apo E; Apolipoprotein E; Apolipoprotein E precursor; apoprotein; Apo Es; Apolipoprotein Es…

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
20331911 Reinvang I, Lundervold AJ, Wehling E, Rootwelt H, Espeseth T: Epistasis between APOE and nicotinic receptor gene CHRNA4 in age related cognitive function and decline. J Int Neuropsychol Soc. 2010 Mar 24:1-9.

The sample was genotyped for apolipoprotein E (APOE) and CHolinergic Receptor for Nicotine Alpha 4 (CHRNA4), and genetic effects on cognitive function at initial testing and on cognitive decline was studied.
86(1,1,1,6) Details
20072115 Marchant NL, King SL, Tabet N, Rusted JM: Positive effects of cholinergic stimulation favor young APOE epsilon4 carriers. Neuropsychopharmacology. 2010 Apr;35(5):1090-6. Epub 2010 Jan 13.

We also explored whether APOE genotype interacts with the cognitive enhancer, nicotine.
83(1,1,1,3) Details
19571461 Kunitomo M, Yamaguchi Y, Kagota S, Yoshikawa N, Nakamura K, Shinozuka K: Biochemical evidence of atherosclerosis progression mediated by increased oxidative stress in apolipoprotein E-deficient spontaneously hyperlipidemic mice exposed to chronic cigarette smoke. J Pharmacol Sci. 2009 Jul;110(3):354-61. Epub 2009 Jul 1.

Apolipoprotein E-deficient spontaneously hyperlipidemic mice, a model of atherosclerosis, were exposed to the gas-phase of smoke, from which tar and nicotine had been removed, for 15 min a day, 6 days a week, for 16 weeks.
7(0,0,1,2) Details