Protein Information

Name c fos
Synonyms Cellular oncogene fos; FBJ murine osteosarcoma viral (v fos) oncogene homolog; FOS; G0/G1 switch regulatory protein 7; G0S7; Oncogene FOS; Proto oncogene protein c fos; c Fos…

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
20147556 Plaza-Zabala A, Martin-Garcia E, de Lecea L, Maldonado R, Berrendero F: Hypocretins regulate the anxiogenic-like effects of nicotine and induce reinstatement of nicotine-seeking behavior. J Neurosci. 2010 Feb 10;30(6):2300-10.

Acute nicotine (0.8 mg/kg, s.c.) induced anxiogenic-like effects in the elevated plus-maze and activated the paraventricular nucleus of the hypothalamus (PVN) as revealed by c-Fos expression.
87(1,1,2,2) Details
19389046 Cheng W, Yin Q, Zeng YM, Wang S, Chen HS, Feng T: Effects of intrathecal injection of nicotine on the analgesic effects of isoflurane in a model of inflammatory pain. Basic Clin Pharmacol Toxicol. 2009 Aug;105(2):120-5. Epub 2009 Mar 16.

The effects of isoflurane and nicotine on paw licking times and formalin-induced c-fos expression in the spinal cord dorsal horn were examined.
7(0,0,1,2) Details
19756526 Mizoguchi H, Arai S, Koike H, Ibi D, Kamei H, Nabeshima T, Kim HC, Takuma K, Yamada K: Therapeutic potential of nicotine for methamphetamine-induced impairment of sensorimotor gating: involvement of pallidotegmental neurons. Psychopharmacology. 2009 Dec;207(2):235-43. Epub 2009 Sep 16.

Nicotine-induced amelioration of PPI deficits in METH-treated mice was accompanied by a reversal of the changes in c-Fos expression in both the LGP and PnC to the basal level.
7(0,0,1,2) Details
20028457 Yu G, Sharp BM: Nicotine self-administration diminishes stress-induced norepinephrine secretion but augments adrenergic-responsiveness in the hypothalamic paraventricular nucleus and enhances adrenocorticotropic hormone and corticosterone release. J Neurochem. 2010 Mar;112(5):1327-37. Epub 2009 Dec 17.

Nicotine self-administration also decreased footshock-induced c-Fos expression in the nucleus of the solitary tract-A2/C2 catecholaminergic neurons that project to the PVN.
6(0,0,1,1) Details
19219614 LaVinka PC, Brand A, Landau VJ, Wirtshafter D, Park TJ: Extreme tolerance to ammonia fumes in African naked mole-rats: animals that naturally lack neuropeptides from trigeminal chemosensory nerve fibers. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2009 May;195(5):419-27. Epub 2009 Feb 15.


Centrally, the number of c Fos labeled cells in the spinal trigeminal nucleus increased from exposure to ammonia although the magnitude of the increase was less than for rats.
1(0,0,0,1) Details
19720621 Zhao-Shea R, Cohen BN, Just H, McClure-Begley T, Whiteaker P, Grady SR, Salminen O, Gardner PD, Lester HA, Tapper AR: Dopamine D2-receptor activation elicits akinesia, rigidity, catalepsy, and tremor in mice expressing hypersensitive {alpha}4 nicotinic receptors via a cholinergic-dependent mechanism. FASEB J. 2010 Jan;24(1):49-57. Epub 2009 Aug 31.


Highlighting the importance of the cholinergic system in this mouse model, inhibiting the effects of ACh by blocking muscarinic receptors, or by selectively activating hypersensitive nAChRs with nicotine, rescued motor symptoms.
0(0,0,0,0) Details