| PubMed |
Abstract |
RScore(About this table) |
| 19594327 |
Singh S, Singh K, Patel DK, Singh C, Nath C, Singh VK, Singh RK, Singh MP: The expression of CYP2D22, an ortholog of human CYP2D6, in mouse striatum and its modulation in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease phenotype and nicotine-mediated neuroprotection. Rejuvenation Res. 2009 Jun;12(3):185-97.
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32(0,1,1,2) |
Details |
| 19019380 |
Petsalo A, Turpeinen M, Pelkonen O, Tolonen A: Analysis of nine drugs and their cytochrome P450-specific probe metabolites from urine by liquid chromatography-tandem mass spectrometry utilizing sub 2 microm particle size column. J Chromatogr A. 2008 Dec 26;1215(1-2):107-15. Epub 2008 Nov 7.
CYP-specific metabolites of melatonin (CYP1A2), nicotine (CYP2A6), bupropion (CYP2B6), repaglinide (CYP2C8), losartan (CYP2C9), omeprazole (CYP2C19 and CYP3A4), dextromethorphan (CYP2D6), chlorzoxazone (CYP2E1) and midazolam (CYP3A4) were all analyzed using the same LC/MS/MS method with a single analytical run, either after a one-at-a-time dose or cocktail-type dosing of the parent drugs. |
31(0,1,1,1) |
Details |
| 20041473 |
Zawertailo LA, Tyndale RF, Busto U, Sellers EM: Effect of metabolic blockade on the psychoactive effects of dextromethorphan. Hum Psychopharmacol. 2010 Jan;25(1):71-9.
OBJECTIVE: Variation in the activity of cytochrome P450 2D6 (CYP2D6) affects the pharmacokinetics and effectiveness of dextromethorphan (DM), because it controls the production of dextrorphan, an active metabolite, with higher affinity for the NMDA receptor than the parent compound. |
4(0,0,0,4) |
Details |