Protein Information

Name basic fibroblast growth factor
Synonyms BFGF; BHBGF 2; BHBGF2; Basic fibroblast growth factor; FGF; FGF2; FGFB; Fibroblast growth factor 2…

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
20307763 Ma L, Zheng LW, Sham MH, Cheung LK: Effect of nicotine on gene expression of angiogenic and osteogenic factors in a rabbit model of bone regeneration. J Oral Maxillofac Surg. 2010 Apr;68(4):777-81.

RESULTS: The messenger ribonucleic acid expression of transforming growth factor beta (1), platelet-derived growth factor A, and basic fibroblast growth factor was significantly inhibited by nicotine exposure at a variety of time points.
82(1,1,1,2) Details
19054295 Nakayama Y, Mezawa M, Araki S, Sasaki Y, Wang S, Han J, Li X, Takai H, Ogata Y: Nicotine suppresses bone sialoprotein gene expression. J Periodontal Res. 2009 Oct;44(5):657-63. Epub 2008 Nov 11.

Nicotine decreased the nuclear protein binding to the cAMP response element (CRE), fibroblast growth factor 2 response element (FRE) and homeodomain protein-binding site (HOX) at 12 and 24 h.
81(1,1,1,1) Details
19410565 Son JH, Winzer-Serhan UH: Chronic neonatal nicotine exposure increases mRNA expression of neurotrophic factors in the postnatal rat hippocampus. Brain Res. 2009 Jun 30;1278:1-14. Epub 2009 May 3.

Therefore, we determined whether chronic neonatal nicotine (CNN) exposure increased mRNA expression levels of brain-derived neurotrophic factor (BDNF), nerve-growth factor (NGF), neurotrophin-3 (NT-3), fibroblast growth factor-2 (FGF-2), and insulin-like growth factor-1 (IGF-1).
6(0,0,1,1) Details
19536709 Herr F, Baal N, Zygmunt M: Studies of placental vasculogenesis: a way to understand pregnancy pathology?. Z Geburtshilfe Neonatol. 2009 Jun;213(3):96-100. Epub 2009 Jun 17.

VEGF, bFGF) as well as pregnancy specific (PlGF, hCG, IGF-II, AFP) angiogenic factors are involved.
Pregnancy-associated exposure to bacterial and viral infections or toxic agents (e. g. alcohol, nicotine or drugs) may also influence vascular development of the placenta and often lead to preterm labour and delivery.
1(0,0,0,1) Details