| Name | JNK1 |
|---|---|
| Synonyms | Mitogen activated protein kinase 8; JNK 1; JNK 46; JNK1; JNK1 alpha protein kinase; JNK1 beta protein kinase; JNK1A2; JNK21B1/2… |
| Name | nicotine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19776730 | Kenney JW, Florian C, Portugal GS, Abel T, Gould TJ: Involvement of hippocampal jun-N terminal kinase pathway in the enhancement of learning and memory by nicotine. Neuropsychopharmacology. 2010 Jan;35(2):483-92. Epub . These data suggest that nicotine and learning interact to alter hippocampal JNK1 gene expression and related signaling processes, thus resulting in strengthened contextual memories. |
81(1,1,1,1) | Details |
| 19892012 | Lin CC, Lee IT, Yang YL, Lee CW, Kou YR, Yang CM: Induction of COX-2/PGE (2)/IL-6 is crucial for cigarette smoke extract-induced airway inflammation: Role of TLR4-dependent oxidase activation. Free Radic Biol Med. 2010 Jan 15;48(2):240-54. Epub 2009 Nov 3. In addition, treatment with nicotine could induce COX-2, PGE (2), and IL-6 generation in in vivo and in vitro studies. Moreover, CSE-regulated COX-2, PGE (2), and IL-6 generation was inhibited by pretreatment with TLR4 Ab; inhibitors of c-Src (PP1), oxidase (diphenylene iodonium and apocynin), p38 MAPK (SB202190), MEK1/2 (U0126), JNK1/2 (SP600125), and NF-kappaB (helenalin); a ROS scavenger (N-acetyl- and transfection with siRNA of TLR4, MyD88, TRAF6, Src, p47 (phox), p38, p42, JNK2, or p65. |
1(0,0,0,1) | Details |