| Name | androgen receptors |
|---|---|
| Synonyms | AIS; AR; Androgen receptor; DHTR; Dihydrotestosterone receptor; HUMARA; KD; NR3C4… |
| Name | lindane |
|---|---|
| CAS | (1α,2α,3β,4α,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19557771 | Di Consiglio E, De Angelis G, Traina ME, Urbani E, Testai E: Effect of lindane on CYP-mediated steroid hormone metabolism in male mice following in utero exposure. J Appl Toxicol. 2009 Nov;29(8):648-55. A wide number of pesticides, including highly persistent organochlorinated compounds, such as lindane (LIN), may induce reproductive and developmental alterations by directly binding to the /androgen receptors or altering steroid hormone metabolism. |
81(1,1,1,1) | Details |
| 1705844 | Simic B, Kniewald Z, Davies JE, Kniewald J: Reversibility of the inhibitory effect of atrazine and lindane on cytosol 5 alpha-dihydrotestosterone receptor complex formation in rat prostate. Bull Environ Contam Toxicol. 1991 Jan;46(1):92-9. |
81(1,1,1,1) | Details |
| 10696776 | Schrader TJ, Cooke GM: Examination of selected food additives and organochlorine food contaminants for androgenic activity in vitro. Toxicol Sci. 2000 Feb;53(2):278-88. In order to produce a reporter gene assay for androgenic chemicals, a constitutive expression vector coding for the human androgen receptor and a reporter construct containing the firefly luciferase coding sequence under transcriptional control of the androgen responsive MMTV promoter were cotransfected into the androgen-insensitive human PC-3 prostate carcinoma cell line and stable transfectants selected. |
2(0,0,0,2) | Details |
| 18992306 | Li J, Li N, Ma M, Giesy JP, Wang Z: In vitro profiling of the endocrine disrupting potency of organochlorine pesticides. Toxicol Lett. 2008 Dec 15;183(1-3):65-71. Epub 2008 Oct 17. The objectives of this study were to determine and compare the ability of p,p'-dichlorodiphenylethane (p,p'-DDE), p,p'-dichlorodiphenyltrichloroethane (p,p'-DDT), hexachlorobenzene (HCB) and r-hexachlorocyclohexane (r-HCH) to interact with ERalpha, androgen receptor (AR), progesterone receptor (PR) and -related receptor (ERRgamma) using a set of recombined yeast strains expressing beta-galactosidase, under control of ERalpha, AR, PR or ERRgamma. |
1(0,0,0,1) | Details |