| Name | isocitrate dehydrogenase |
|---|---|
| Synonyms | ICD M; IDH; IDP; NADP(+) specific ICDH; Oxalosuccinate decarboxylase; IDH 2; IDH2; IDHM… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 4146799 | Moyle J, Mitchell P: The -translocating transhydrogenase of rat liver mitochondria. Biochem J. 1973 Mar;132(3):571-85. The NAD-linked isocitrate dehydrogenase activity was destroyed by an endogenous autolytic system or by added nucleotide pyrophosphatase, and was restored by a catalytic amount of 2. During oxidation of by in intact, anaerobic, mitochondria via the rhein-sensitive, but rotenone- and arsenite-insensitive, NAD (P) transhydrogenase, measurements of the rates of carbonyl p-trifluoromethoxyphenylhydrazone-sensitive and carbonyl p-trifluoromethoxyphenylhydrazone-insensitive pH change in the presence of various / concentration ratios gave an --> H (+)/2e (-) quotient of 1.94+/-0.12 for outward translocation by the NAD (P) transhydrogenase. 4. |
2(0,0,0,2) | Details |
| 16667685 | Pascal N, Dumas R, Douce R: Comparison of the Kinetic Behavior toward Nucleotides of -Linked Dehydrogenases from Plant Mitochondria. Plant Physiol. 1990 Sep;94(1):189-193. In this article we compare the kinetic behavior toward nucleotides (+), of (+)-malic enzyme, pyruvate dehydrogenase, isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, and glycine decarboxylase extracted from pea (Pisum sativum) leaf and potato (Solanum tuberosum) tuber mitochondria. It is suggested that (+)-linked malic enzyme, when fully activated, is able to raise the matricial level up to the required concentration to fully engage the rotenone-resistant internal NADH-dehydrogenase, whose affinity for is weaker than complex I. |
1(0,0,0,1) | Details |
| 11337409 | Moller IM: PLANT MITOCHONDRIA AND OXIDATIVE STRESS: Electron Transport, Turnover, and Metabolism of Reactive Species. Annu Rev Plant Physiol Plant Mol Biol. 2001 Jun;52:561-591. In addition to complexes I-IV, the plant mitochondrial ETC contains a non--pumping alternative oxidase as well as two rotenone-insensitive, non--pumping NAD (P) H dehydrogenases on each side of the inner membrane: NDex on the outer surface and NDin on the inner surface. The antioxidants are kept in a reduced state by matrix produced by -isocitrate dehydrogenase and non--pumping transhydrogenase activities. |
1(0,0,0,1) | Details |
| 8390371 | Komuniecki PR, Johnson J, Kamhawi M, Komuniecki R: Mitochondrial heterogeneity in the parasitic nematode, Ascaris suum. Exp Parasitol. 1993 Jun;76(4):424-37. However, the activities of several tricarboxylic acid cycle enzymes, including citrate synthase and isocitrate dehydrogenase, were about 100-fold higher in testis/seminal vesicle mitochondria than muscle mitochondria. The incorporation of 32Pi into organic by either muscle or testis/seminal vesicle mitochondria appeared to be dependent on and and incorporation was inhibited by rotenone but not |
1(0,0,0,1) | Details |
| 16663145 | Laties GG: Membrane-Associated NAD-Dependent Isocitrate Dehydrogenase in Potato Mitochondria. Plant Physiol. 1983 Aug;72(4):953-958. Whereas in intact mitochondria the activity of the membrane-bound enzyme is insensitive to rotenone, and to butylmalonate, an inhibitor of organic acid transport, oxidation by the soluble matrix enzyme is inhibited by both. |
3(0,0,0,3) | Details |
| 6682758 | Evans CT, Scragg AH, Ratledge C: Regulation of efflux from mitochondria of oleaginous and non-oleaginous yeasts by nucleotides. Eur J Biochem. 1983 May 16;132(3):609-15. To explain these observations the mitochondrial NAD+-dependent isocitrate dehydrogenase was studied in a number of yeasts. The effects of ATP and AMP were not observed in mitochondria whose metabolism had been inhibited by antimycin A and rotenone indicating the direct regulation of the translocase was not involved. 3. |
2(0,0,0,2) | Details |
| 16828729 | Benit P, Goncalves S, Philippe Dassa E, Briere JJ, Martin G, Rustin P: Three spectrophotometric assays for the measurement of the five respiratory chain complexes in minuscule biological samples. Clin Chim Acta. 2006 Dec;374(1-2):81-6. Epub 2006 Jun 2. A second assay measures the activity of complex II followed by dehydrogenase and isocitrate dehydrogenase. A third assay measures rotenone-sensitive complex I activity and subsequently oligomycin-sensitive complex V activity. |
1(0,0,0,1) | Details |
| 3214168 | Moore GA, Weis M, Orrenius S, O'Brien PJ: Role of sulfhydryl groups in -induced Ca2+ release by rat liver mitochondria. Arch Biochem Biophys. 1988 Dec;267(2):539-50. Incubation of rat liver mitochondria with derivatives in the presence of plus rotenone has been shown to cause NAD (P) H oxidation followed by Ca2+ release. Isocitrate dehydrogenase was also inhibited by but the cofactors NAD (P) H and Mn2+ protected the enzyme. |
1(0,0,0,1) | Details |
| 19763263 | Johnson F, Kaplitt MG: Novel mitochondrial substrates of omi indicate a new regulatory role in neurodegenerative disorders. PLoS One. 2009 Sep 18;4(9):e7100. Additionally our gene expression studies, using rotenone (an inhibitor of Complex I) showed Omi expression was silenced when pdhb and idh3a were increased when a sub-lethal dose was applied. Pyruvate dehydrogenase (PDH) and isocitrate dehydrogenase (IDH) are two key Kreb's cycle enzymes that catalyse oxidative decarboxylation control points in mitochondrial respiration. |
1(0,0,0,1) | Details |
| 3990291 | Swierczynski J, Klimek J, Zelewski L: The role of malic enzyme in the dependent biosynthesis of in the mitochondrial fraction of human term placenta. J Steroid Biochem. 1985 Mar;22(3):415-8. While mitochondria were incubated in the presence of Mn2+ the formation was stimulated significantly both by NAD+ and and was inhibited by hydroxymalonate, arsenite, butylmalonate and rotenone. |
0(0,0,0,0) | Details |