| Name | VDAC |
|---|---|
| Synonyms | Outer mitochondrial membrane protein porin 1; PORIN; PORIN 31 HL; Plasmalemmal porin; Porin 31HL; Porin 31HM; VDAC; VDAC 1… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18802751 | Xiong Y, Ding H, Xu M, Gao J: Protective effects of asiatic acid on rotenone- or H2O2-induced injury in SH-SY5Y cells. Neurochem Res. 2009 Apr;34(4):746-54. Epub 2008 Sep 19. More interestingly, pre-administration of AA inhibited the elevation of VDAC mRNA and protein levels induced by rotenone (100 nM) or H (2) O (2) (300 microM).These data indicate that AA could protect neuronal cells against mitochondrial dysfunctional injury and suggest that AA might be developed as an agent for PD prevention or therapy. |
32(0,1,1,2) | Details |
| 10816428 | Doran E, Halestrap AP: Cytochrome c release from isolated rat liver mitochondria can occur independently of outer-membrane rupture: possible role of contact sites. Biochem J. 2000 Jun 1;348 Pt 2:343-50. Dextran also inhibited both mitochondrial oxidation of exogenous ferrocytochrome c in the presence of rotenone and antimycin, and respiratory-chain-driven reduction of exogenous ferricytochrome c. Polyaspartate, which stabilizes the low conductance state of the voltage-dependent anion channel (VDAC), increased cytochrome c release. |
3(0,0,0,3) | Details |