| Name | MEK1 |
|---|---|
| Synonyms | Dual specificity mitogen activated protein kinase kinase 1; ERK activator kinase 1; MAP kinase kinase 1; MAP2K1; MAPK/ERK kinase 1; MAPKK 1; MAPKK1; MEK 1… |
| Name | lindane |
|---|---|
| CAS | (1α,2α,3β,4α,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15888667 | Ledirac N, Antherieu S, d'Uby AD, Caron JC, Rahmani R: Effects of organochlorine insecticides on MAP kinase pathways in human HaCaT keratinocytes: key role of reactive species. Toxicol Sci. 2005 Aug;86(2):444-52. Epub 2005 May 11. The aim of this study was to investigate the effects of four OCs (dieldrin, endosulfan, heptachlor, and lindane) on mitogen-activated protein kinase (MAPK) cascades and more specifically to identify the mechanism underlying OC-induced ERK1/2 activation. Moreover, blockade of Raf, MEK1/2, or PKC activation with geldanamycin, U0126, or calphostin C inhibited ERK1/2 phosphorylation, demonstrating a PKC-Raf-MEK1/2 pathway. |
1(0,0,0,1) | Details |
| 17102581 | Corcelle E, Djerbi N, Mari M, Nebout M, Fiorini C, Fenichel P, Hofman P, Poujeol P, Mograbi B: Control of the autophagy maturation step by the MAPK ERK and p38: lessons from environmental carcinogens. Autophagy. 2007 Jan-Feb;3(1):57-9. Epub 2007 Jan 21. Our work published in Cancer Research revealed that the sustained activation of the MAPK ERK pathway by the carcinogen Lindane or the MEK1 (+) oncogene alters autophagy selectively at the maturation step resulting in the accumulation of large defective autolysosomes. |
31(0,1,1,1) | Details |
| 12807735 | Mograbi B, Corcelle E, Defamie N, Samson M, Nebout M, Segretain D, Fenichel P, Pointis G: Aberrant Connexin 43 endocytosis by the carcinogen lindane involves activation of the ERK/mitogen-activated protein kinase pathway. Carcinogenesis. 2003 Aug;24(8):1415-23. Epub 2003 Jun 5. Inhibition of ERK pathway by PD98059, a MEK1-specific inhibitor, prevented Lindane-induced Cx43 phosphorylation, restored Cx43 membranous localization and gap junction coupling. |
31(0,1,1,1) | Details |