| Name | Acetylcholinesterase |
|---|---|
| Synonyms | ACHE; ACHE protein; AChE; ARACHE; AcChoEase; Acetylcholine acetylhydrolase; Acetylcholinesterase; Acetylcholinesterase isoform E4 E6 variant… |
| Name | chlorpyrifos-methyl |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12791540 | Kropp TJ, Richardson RJ: Relative inhibitory potencies of chlorpyrifos oxon, chlorpyrifos methyl oxon, and mipafox for acetylcholinesterase versus neuropathy target esterase. J Toxicol Environ Health A. 2003 Jun 27;66(12):1145-57. |
34(0,1,1,4) | Details |
| 17723768 | Arduini F, Ricci F, Tuta CS, Moscone D, Amine A, Palleschi G: Detection of carbamic and organophosphorous pesticides in water samples using a cholinesterase biosensor based on Prussian Blue-modified screen-printed electrode. Anal Chim Acta. 2006 Nov 24;580(2):155-62. Epub 2006 Jul 29. AChE-based biosensors have demonstrated a higher sensitivity towards aldicarb (50% inhibition with 50 ppb) and carbaryl (50% inhibition with 85 ppb) while BChE biosensors have shown a higher affinity towards paraoxon (50% inhibition with 4 ppb) and chlorpyrifos-methyl oxon (50% inhibition with 1 ppb). |
32(0,1,1,2) | Details |
| 9880902 | Gao JR, Rao JV, Wilde GE, Zhu KY: Purification and kinetic analysis of acetylcholinesterase from western corn rootworm, Diabrotica virgifera virgifera (Coleoptera: Chrysomelidae). Arch Insect Biochem Physiol. 1998;39(3):118-25. Insecticides or their oxidative metabolites, chlorpyrifos-methyl oxon, carbofuran, carbaryl, malaoxon, and paraoxon, used in in vitro kinetic study exhibited high inhibition to AChE purified from WCR. |
6(0,0,0,6) | Details |
| 10630569 | Steevens JA, Benson WH: Toxicological interactions of chlorpyrifos and methyl mercury in the amphipod, Hyalella azteca. Toxicol Sci. 1999 Dec;52(2):168-77. Results of thin layer chromatography suggested the formation of a chlorpyrifos-methyl mercury complex. Biochemical endpoints that were evaluated include the inhibition of acetylcholinesterase enzyme and indicators of oxidative stress such as glutathione-S-transferase activity, lipid peroxidation, protein oxidation, and content. |
3(0,0,0,3) | Details |
| 16289700 | Abdel-Halim KY, Salama AK, El-Khateeb EN, Bakry NM: Organophosphorus pollutants (OPP) in aquatic environment at Damietta Governorate, Egypt: implications for monitoring and biomarker responses. Chemosphere. 2006 Jun;63(9):1491-8. Epub 2005 Nov 14. The obtained results are in parallel to that found in case of cholinesterase activity where the activity of both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) was declined at these seasonal period. Chlorpyrifos, chlorpyrifos-methyl, malathion, diazinon, pirimiphos-methyl and profenofos were detected in most samples. |
3(0,0,0,3) | Details |
| 11460676 | Steevens JA, Benson WH: Interactions of chlorpyrifos and methyl mercury: a mechanistic approach to assess chemical mixtures. Mar Environ Res. 2000 Jul-Dec;50(1-5):113-7. To further examine the mechanism responsible for these interactions, the in vivo and in vitro inhibition of acetylcholinesterase enzyme activity was assessed following exposure to methyl mercury and chlorpyrifos. Chemical-chemical interactions were examined utilizing chromatographic techniques and suggested the formation of a chlorpyrifos-methyl mercury complex. |
3(0,0,0,3) | Details |
| 17915512 | Djogbenou L, Weill M, Hougard JM, Raymond M, Akogbeto M, Chandre F: Characterization of insensitive acetylcholinesterase (ace-1R) in Anopheles gambiae (Diptera: Culicidae): resistance levels and dominance. J Med Entomol. 2007 Sep;44(5):805-10. Furthermore, the dominance status varied between semi-recessivity with fenitrothion and chlorpyrifos methyl insecticides to semidominance with temephos, carbosulfan, and propoxur. |
2(0,0,0,2) | Details |
| 6193610 | Pellissier C, Leung Tack D, Gras G: [Effect of temephos on acetylcholinesterase activity in the brain of Tilapia guineensis. 3: Comparative effect of temephos and 3 substitute insecticides]. Toxicol Eur Res. 1983 Mar;5(2):63-9. Among these, chlorphoxim, chlorpyrifos-methyl and pirimiphos-methyl proved to be the most effect of these three organophosphorus compounds to that of temephos on the acetylcholinesterasic activity of the brain of Tilapia but using a much higher dosage (0,05 mg/l during 24 hrs that is 144 times more than for temephos). |
2(0,0,0,2) | Details |
| 17824663 | Walz I, Schwack W: Cutinase inhibition by means of insecticidal organophosphates and carbamates. 3. J Agric Food Chem. 2007 Oct 3;55(20):8177-86. Epub 2007 Sep 8. Chloroperoxidase (CPO) from Caldariomyces fumago combined with peroxide and proved to be most efficient for the transformation of organophosphorothionate pesticides, i.e., chlorpyrifos, chlorpyrifos-methyl, parathion, and parathion-methyl, into their more potent serine esterase inhibiting oxon analogues. This type of enzymatic oxidation is easier to perform and more efficient, as compared to or N-bromosuccinimide, used for acetylcholine esterase (AChE) assay in water analyses, but is insufficient for complex matrices such as plant sample extracts. |
1(0,0,0,1) | Details |
| 19674799 | Tryfonos M, Papaefthimiou C, Antonopoulou E, Theophilidis G: Comparing the inhibitory effects of five protoxicant organophosphates (azinphos-methyl, parathion-methyl, chlorpyriphos-methyl, methamidophos and diazinon) on the spontaneously beating auricle of Sparus aurata: an in vitro study. Aquat Toxicol. 2009 Sep 14;94(3):211-8. Epub 2009 Jul 16. Organophosphates (OPs) can provoke toxicity by inhibiting acetylcholinesterase (AChE) in non-target organisms, like fish. |
1(0,0,0,1) | Details |
| 12452633 | Del Carlo M, Mascini M, Pepe A, Compagnone D, Mascini M: Electrochemical bioassay for the investigation of chlorpyrifos-methyl in vine samples. J Agric Food Chem. 2002 Dec 4;50(25):7206-10. The analytical method was based on electrochemical determination of the extent of the inhibition exerted by the pesticide on acetylcholinesterase using the substrate acetylthiocholine. |
1(0,0,0,1) | Details |
| 15918909 | Asidi AN, N'Guessan R, Koffi AA, Curtis CF, Hougard JM, Chandre F, Corbel V, Darriet F, Zaim M, Rowland MW: Experimental hut evaluation of bednets treated with an organophosphate (chlorpyrifos-methyl) or a pyrethroid (lambdacyhalothrin) alone and in combination against insecticide-resistant Anopheles gambiae and Culex quinquefasciatus mosquitoes. Malar J. 2005 May 26;4(1):25. Anopheles gambiae and Culex quinquefasciatus mosquitoes from the area are resistant to pyrethroids and organophosphates (kdr and insensitive acetylcholinesterase Ace.1R). |
1(0,0,0,1) | Details |
| 11425027 | Lee SE, Lees EM: Biochemical mechanisms of resistance in strains of Oryzaephilus surinamensis (Coleoptera: Silvanidae) resistant to malathion and chlorpyrifos-methyl. J Econ Entomol. 2001 Jun;94(3):706-13. The acetylcholinesterase, carboxylesterase, and cytochrome P450 monooxygenase activities of three strains of Oryzaephilus srinamensis (L.) were examined to better understand biochemical mechanisms of resistance. |
1(0,0,0,1) | Details |