| PubMed |
Abstract |
RScore(About this table) |
| 2160188 |
Rodgers KE, Ellefson DD: Modulation of macrophage protease activity by acute administration of O,O,S trimethyl phosphorothioate. Agents Actions. 1990 Mar;29(3-4):277-85.
Previous studies showed that acute administration of O,O,S trimethyl phosphorothioate (OOS-TMP), a contaminant in malathion, acephate and fenitrothion, led to increases in metabolic activities, such as, secretion of interleukin 1 and nonspecific esterase, of splenic and peritoneal macrophages. |
81(1,1,1,1) |
Details |
| 12039681 |
Singh AK: Acute effects of acephate and methamidophos and interleukin-1 on corticotropin-releasing factor (CRF) synthesis in and release from the hypothalamus in vitro. Comp Biochem Physiol C Toxicol Pharmacol. 2002 May;132(1):9-24.
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36(0,1,1,6) |
Details |
| 12355557 |
Singh AK, Jiang Y: Immunotoxicity of acute acephate exposure in control or IL-1-challenged rats: correlation between the immune cell composition and corticosteroid concentration in blood. J Appl Toxicol. 2002 Sep-Oct;22(5):279-91.
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21(0,0,2,11) |
Details |
| 15697179 |
Singh AK, Jiang Y: Lipopolysaccharide (LPS) induced activation of the immune system in control rats and rats chronically exposed to a low level of the organothiophosphate insecticide, acephate. Toxicol Ind Health. 2003 Jul;19(2-6):93-108.
This study showed that LPS injection in control rats caused (1) a time-dependent increase in blood lymphocyte enumeration and differentiation, and (2) a sequential increase the pro-inflammatory (interleukin-1beta (IL1beta), tumor necrosis factor-alpha (TNFalpha), interferon-gamma (INTgamma), and inducible nitric oxide synthase (iNOS)) and anti-inflammatory (interleukin-4 (IL-4), corticotropin-releasing factor (CRF), and blood corticosterone (Cort)) cytokines. |
1(0,0,0,1) |
Details |