Protein Information

Name C type lectins (protein family or complex)
Synonyms C type lectin like receptor; C type lectin like receptors; C type lectin; C type lectin domain family; C type lectins

Compound Information

Name EPN
CAS

Reference List

PubMed Abstract RScore(About this table)
16542855 Nikolakopoulou K, Zarkadis IK: Molecular cloning and characterisation of two homologues of Mannose-Binding Lectin in rainbow trout. Fish Shellfish Immunol. 2006 Sep;21(3):305-14. Epub 2006 Mar 15.


C-type lectins are all Ca (2+)-dependent molecules and they share a tightly folded carbohydrate recognition domain (CRD).
2(0,0,0,2) Details
17169576 Gourdine JP, Smith-Ravin EJ: Analysis of a cDNA-derived sequence of a novel mannose-binding lectin, codakine, from the tropical clam Codakia orbicularis. Fish Shellfish Immunol. 2007 May;22(5):498-509. Epub 2006 Jul 10.


BLAST analysis revealed about 23% to 29% sequence identity between codakine and various animal C-type lectins that are often involved in symbiosis and immune defences.
2(0,0,0,2) Details
15096474 Takahara K, Yashima Y, Omatsu Y, Yoshida H, Kimura Y, Kang YS, Steinman RM, Park CG, Inaba K: Functional comparison of the mouse DC-SIGN, SIGNR1, SIGNR3 and Langerin, C-type lectins. Int Immunol. 2004 Jun;16(6):819-29. Epub 2004 Apr 19.

2(0,0,0,2) Details
15261461 Savan R, Endo M, Sakai M: Characterization of a new C-type lectin from common carp Cyprinus carpio. Mol Immunol. 2004 Jul;41(9):891-9.


The gene is composed of 146 amino acid residues, including an 18-residue signal peptide for secretion and a single carbohydrate-recognition domain of approximately 118 residues typical of C-type lectins.
1(0,0,0,1) Details
20211738 Zhang H, Kong P, Wang L, Zhou Z, Yang J, Zhang Y, Qiu L, Song L: Cflec-5, a pattern recognition receptor in scallop Chlamys farreri agglutinating yeast Pichia pastoris. Fish Shellfish Immunol. 2010 Mar 6.


C-type lectins are a superfamily of carbohydrate-recognition proteins which play crucial roles as pattern recognition receptors (PRRs) in the innate immunity.
1(0,0,0,1) Details
18793643 Ma TH, Benzie JA, He JG, Chan SM: PmLT, a C-type lectin specific to hepatopancreas is involved in the innate defense of the shrimp Penaeus monodon. J Invertebr Pathol. 2008 Nov;99(3):332-41. Epub 2008 Aug 30.


Despite the low overall amino acid sequence identity with other animal lectins, PmLT includes conserved carbohydrate recognition domains (CRDs) characteristic of animal C-type lectins.
1(0,0,0,1) Details
20026605 Tateno H, Ohnishi K, Yabe R, Hayatsu N, Sato T, Takeya M, Narimatsu H, Hirabayashi J: Dual specificity of Langerin to sulfated and mannosylated glycans via a single C-type carbohydrate recognition domain. J Biol Chem. 2010 Feb 26;285(9):6390-400. Epub 2009 Dec 21.


Langerin showed outstanding affinity to galactose-6-sulfated oligosaccharides, including keratan sulfate, while it preserved binding activity to mannose, as a common feature of the C-type lectins with an EPN motif.
1(0,0,0,1) Details
12667617 Richards RC, Hudson DM, Thibault P, Ewart KV: Cloning and characterization of the Atlantic salmon serum lectin, a long-form C-type lectin expressed in kidney. Biochim Biophys Acta. 2003 Apr 7;1621(1):110-5.


Sequence alignments and intron/exon structure of the SSL gene showed it to belong to the type VII C-type lectins, which normally bind to galactose or other ligands, whereas the SSL protein sequence contains the EPN motif of mannose-binding C-type lectins, that bind mannose or related carbohydrates.
1(0,0,0,1) Details
18945787 Zhao ZY, Yin ZX, Xu XP, Weng SP, Rao XY, Dai ZX, Luo YW, Yang G, Li ZS, Guan HJ, Li SD, Chan SM, Yu XQ, He JG: A novel C-type lectin from the shrimp Litopenaeus vannamei possesses anti-white spot syndrome virus activity. J Virol. 2009 Jan;83(1):347-56. Epub 2008 Oct 22.


C-type lectins play key roles in pathogen recognition, innate immunity, and cell-cell interactions.
1(0,0,0,1) Details
17276083 Ma TH, Tiu SH, He JG, Chan SM: Molecular cloning of a C-type lectin (LvLT) from the shrimp Litopenaeus vannamei: early gene down-regulation after WSSV infection. Fish Shellfish Immunol. 2007 Aug;23(2):430-7. Epub 2006 Dec 19.


The deduced LvLT consists of two putative carbohydrate-recognition domains (CRDs) as found in most C-type lectins.
1(0,0,0,1) Details