Protein Information

Name alkaline phosphatase
Synonyms ALP 1; Alkaline phosphatase; ALPG; ALPPL; ALPPL 2; ALPPL2; GCAP; Germ cell alkaline phosphatase…

Compound Information

Name HCH
CAS 1,2,3,4,5,6-hexachlorocyclohexane

Reference List

PubMed Abstract RScore(About this table)
1714421 Dikshith TS, Raizada RB, Singh V, Pandey M, Srivastava MK: Repeated dermal toxicity of technical HCH and methyl parathion (50EC) to female rats (Rattus norvigicus). Indian J Exp Biol. 1991 Feb;29(2):149-55.

Repeated dermal application of hexachlorocyclohexane (HCH; 100 mg/kg/day) or methyl parathion (2 mg/kg/day) individually or in combination for 7, 15 and 30 days produced pathomorphological changes in skin, liver, kidney and brain of female rats along with significant enzymatic alterations in the activity of transaminase, alkaline phosphatase lactic dehydrogenase and acetylcholinesterase.
6(0,0,1,1) Details
1838687 Carvalho WA: [Risk factors related with occupational and environmental exposure to organochlorine insecticides in the state of Bahia, Brazil, 1985]. Bol Oficina Sanit Panam. 1991 Dec;111(6):512-24.


It was found that improper handling of the products and failure to use individual protective equipment, together with longer time of exposure, significantly increased the rates of GOT and GPT in the appliers of DDT and technical HCH, and in the latter the rates of alkaline phosphatase, albumin, and cholesterol were also found to be higher.
1(0,0,0,1) Details
2465584 Dikshith TS, Carrera G, Raizada RB, Mitjavila S: Interaction of hexachlorocyclohexane (HCH) and chlorpropham (CIPC) in male rats. Toxicol Lett. 1989 Feb;45(2-3):281-8.

The significant rise in the activity of alkaline phosphatase in liver and serum and of GOT and GPT in liver with substantial weight increase of liver has been suggestive of the initiation of biochemical lesions and adaptation of the organism.
1(0,0,0,1) Details
11811620 Labana S, Bansal RC, Mahmood A: Age related effects of organochlorine insecticide lindane on intestinal brush border membrane in rats. Indian J Biochem Biophys. 2001 Aug;38(4):249-52.


In 10 day-old suckling pups exposed to lindane, there was a significant decrease in the activities of sucrase (29%), lactase (20%) and that of alkaline phosphatase (24%) compared to control.
1(0,0,0,1) Details
2445294 Akaza H, Kameyama S, Aso Y: [Significance of tumor markers in the treatment of urological malignancies]. Gan To Kagaku Ryoho. 1987 Nov;14(11):3034-40.

Clinical and laboratory studies have confirmed the efficacy of alpha-fetoprotein (AFP) and human chorionic gonadotropin (hCH) as tumor markers in the diagnosis, monitoring and assessment of prognosis in cases of testicular tumor.
Thus, serum alkaline phosphatase and urinary hydroxyproline are considered to be useful markers for indicating bone involvement.
1(0,0,0,1) Details
2481647 Ravinder P, Srinivasan K, Radhakrishnamurty R: Biochemical toxicity of hexachlorocyclohexane and its gamma-isomer in albino mice. Indian J Exp Biol. 1989 Mar;27(3):248-51.


Elevated levels of alanine and aspartate aminotransferases and of alkaline phosphatase in the blood of these animals suggested hepatotoxicity.
1(0,0,0,1) Details
16838206 Wang F, Xu ZR, Sun JH: Effect of HCH contamination of diet on the growth performance and immune and antioxidant ability in growing/finishing pigs. Vet Res Commun. 2006 Aug;30(6):645-54.


Moreover, the activities of serum alanine aminotransferase and alkaline phosphatase were increased significantly.
1(0,0,0,1) Details