Protein Information

Name glucose 6 phosphate dehydrogenase
Synonyms 6 phosphogluconolactonase; GDH; G6PDH; Glucose 6 phosphate dehydrogenase; GDH/6PGL endoplasmic bifunctional protein; GDH/6PGL endoplasmic bifunctional protein precursor; Glucose 1 dehydrogenase; Glucose dehydrogenase…

Compound Information

Name HCH
CAS 1,2,3,4,5,6-hexachlorocyclohexane

Reference List

PubMed Abstract RScore(About this table)
6188322 Shivanandappa T, Krishnakumari MK: Hexachlorocyclohexane-induced testicular dysfunction in rats. Acta Pharmacol Toxicol. 1983 Jan;52(1):12-7.

Activities of delta 5 3 beta hydroxysteroid dehydrogenase (delta 5 3 beta HSDH), 17 beta hydroxysteroid dehydrogenase (17 beta HSDH) and glucose-6-phosphate dehydrogenase (G-6-PDH) in the interstitial cells were markedly decreased suggesting steroidogenic inhibition in the Leydig cells of the atrophied testis due to HCH feeding.
31(0,1,1,1) Details
17123163 Anilakumar KR, Khanum F, Santhanam K: Amelioration of hexachlorocyclohexane-induced oxidative stress by amaranth leaves in rats. Plant Foods Hum Nutr. 2006 Dec;61(4):169-73.


Feeding of AL at 10% level increased the hepatic glucose-6-phosphate dehydrogenase (G-6-PDH) activity while that at 20% level increased the hepatic glutathione reductase (GSSGR) as well, in addition to G-6-PDH.
1(0,0,0,1) Details
18940228 Anilakumar KR, Saritha V, Khanum F, Bawa AS: Ameliorative effect of ajwain extract on hexachlorocyclohexane-induced lipid peroxidation in rat liver. Food Chem Toxicol. 2009 Feb;47(2):279-82. Epub 2008 Oct 4.


Results revealed that HCH administration lead to an increase in hepatic lipid peroxidation associated with reduction in, levels of glutathione (GSH), activity of superoxide dismutase (SOD), catalase and glucose-6-phosphate dehydrogenase.
1(0,0,0,1) Details
2461408 Srinivasan K, Radhakrishnamurty R: Biochemical changes produced by beta- and gamma-hexachlorocyclohexane isomers in albino rats. J Environ Sci Health B. 1988 Aug;23(4):367-86.


Treatment of rats with beta- and gamma-isomers of HCH increased the hepatic glucose-6-phosphate dehydrogenase and aldolase activities suggesting a higher rate of glucose oxidation.
1(0,0,0,1) Details
7504364 Prabhakaran S, Shameem F, Devi KS: Influence of protein deficiency on hexachlorocyclohexane and malathion toxicity in pregnant rats. Vet Hum Toxicol. 1993 Oct;35(5):429-33.


Depletion in glutathione (GSH) and decreased activities of GSH peroxidase, GSH reductase and glucose-6-phosphate dehydrogenase were observed from the protein deficiency and pesticide exposure.
1(0,0,0,1) Details
1708174 Barros SB, Simizu K, Junqueira VB: Liver lipid peroxidation-related parameters after short-term administration of hexachlorocyclohexane isomers to rats. Toxicol Lett. 1991 Apr;56(1-2):137-44.


Other parameters studied were liver glucose-6-phosphate dehydrogenase, glutathione peroxidase, glutathione reductase and catalase (CAT) activities.
1(0,0,0,1) Details
8519523 Prasad AK, Pant N, Srivastava SC, Kumar R, Srivastava SP: Effect of dermal application of hexachlorocyclohexane (HCH) on male reproductive system of rat. Hum Exp Toxicol. 1995 Jun;14(6):484-8.


The results indicate that exposure of HCH through the dermal route could lead to an alteration in the activities of marker testicular enzymes viz. sorbitol dehydrogenase (SDH), glucose-6-P-dehydrogenase (G6PDH), gamma-glutamyl transpeptidase (gamma-GT) and beta-glucuronidase (beta Gluc.) associated with specific cell types. 3.
1(0,0,0,1) Details