Protein Information

Name glutathione S transferase
Synonyms GST class alpha 2; Gst2; GST class alpha; GST class alpha member 2; GST gamma; GSTA 2; GSTA2; GSTA2 2…

Compound Information

Name gamma-HCH
CAS (1α,2α,3β,4α,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane

Reference List

PubMed Abstract RScore(About this table)
12038708 Iscan M, Coban T, Cok I, Bulbul D, Eke BC, Burgaz S: The organochlorine pesticide residues and antioxidant enzyme activities in human breast tumors: is there any association?. Breast Cancer Res Treat. 2002 Mar;72(2):173-82.

The levels of some organochlorine pesticides (OCP) s (hexachlorobenzene, HCB, alpha-hexachlorocyclohexane, alpha-HCH, beta-HCH, gamma-HCH, heptachlorepoxide, HE, bis (4-chlorophenyl)-1,1-dichloroethene, p.p'DDE, bis (4-chlorophenyl)-1,1,1-trichloroethane, p.p' DDT and total DDT (E-DDT) and antioxidant enzyme activities namely Cu, Zn superoxide dismutase (SOD), catalase (CAT), selenium-dependent glutathione peroxidase (Se-GSH-Px), total glutathione peroxidase (T-GSH-Px), selenium independent glutathione peroxidase (GSH-Px II), glutathione reductase (GRd), level of reduced glutathione (GSH) and lipid peroxidation (LP), glutathione S-transferase (GST) activity toward several substrates including 1-chloro-2,4-dinitrobenzene (CDNB), 1,2-dichloro-4-nitrobenzene (DCNB), ethacrynic acid (EAA), 1,2-epoxy-3-(p-nitrophenoxy)-propane (ENPP) were measured in tumor and surrounding tumor free tissues of 24 female breast cancer patients and was evaluated whether there exist any association between the levels of OCPs and antioxidants.
31(0,1,1,1) Details
16156589 Kristensen M: Glutathione S-transferase and insecticide resistance in laboratory strains and field populations of Musca domestica. J Econ Entomol. 2005 Aug;98(4):1341-8.

2(0,0,0,2) Details
17618397 Elia AC, Dorr AJ, Galarini R: Comparison of organochlorine pesticides, PCBs, and heavy metal contamination and of detoxifying response in tissues of Ameiurus melas from Corbara, Alviano, and Trasimeno Lakes, Italy. Bull Environ Contam Toxicol. 2007 Jun;78(6):463-8. Epub 2007 Jul 7.

Accumulation of cadmium (Cd), mercury (Hg), lead (Pb), chromium (Cr), hexachlorobenzene, gamma-HCH, DDTs, and PCBs has been investigated in the muscle of Ameiurus melas sampled during the same period from Lake Corbara, Alviano, and Trasimeno.
Glutathione content and the enzymatic activities of glutathione reductase, glutathione peroxidase, catalase, glutathione S-transferase, and glyoxalase I were examined in gills, liver, and kidneys of each specimen.
1(0,0,0,1) Details
9515900 Miyauchi K, Suh SK, Nagata Y, Takagi M: Cloning and sequencing of a 2,5-dichlorohydroquinone reductive dehalogenase gene whose product is involved in degradation of gamma-hexachlorocyclohexane by Sphingomonas paucimobilis. J Bacteriol. 1998 Mar;180(6):1354-9.


The linD gene encodes a peptide of 343 amino acids and has a low level of similarity to proteins which belong to the glutathione S-transferase family.
1(0,0,0,1) Details
15382504 Kristensen M, Jespersen JB, Knorr M: Cross-resistance potential of fipronil in Musca domestica. Pest Manag Sci. 2004 Sep;60(9):894-900.


Biochemical assays of esterase, glutathione S-transferase and cytochrome P450 monooxygenase indicated that the low fipronil resistance observed in laboratory and field strains could be caused by elevated detoxification or be due to a target-site resistance mechanism with cross-resistance to gamma-HCH.
1(0,0,0,1) Details