Protein Information

Name sex hormone binding globulin
Synonyms ABP; SBP; Androgen binding protein; SHBG; Sex hormone binding globulin; Sex hormone binding globulin precursor; Sex steroid binding protein; TeBG…

Compound Information

Name TDE
CAS 1,1′-(2,2-dichloroethylidene)bis[4-chlorobenzene]

Reference List

PubMed Abstract RScore(About this table)
12034517 Campagnoli C, Colombo P, De Aloysio D, Gambacciani M, Grazioli I, Nappi C, Serra GB, Genazzani AR: Positive effects on cardiovascular and breast metabolic markers of oral estradiol and dydrogesterone in comparison with transdermal estradiol and norethisterone acetate. Maturitas. 2002 Apr 25;41(4):299-311.

They were randomized to a treatment of six 28-day cycles with oral estradiol sequentially combined with dydrogesterone (oE2/D10) or a sequential combination patch of estradiol plus norethisterone acetate (tdE/NETA).
At baseline and after six cycles the high-density lipoprotein cholesterol (HDL-C), the sex hormone binding globulin (SHBG) and the total insulin-like growth factor-I (IGF-I) blood levels were determined by a central laboratory.
4(0,0,0,4) Details
15641029 Bland LB, Garzotto M, DeLoughery TG, Ryan CW, Schuff KG, Wersinger EM, Lemmon D, Beer TM: Phase II study of transdermal estradiol in androgen-independent prostate carcinoma. Cancer. 2005 Feb 15;103(4):717-23.


The total testosterone level remained stable in the anorchid range during treatment, but the free testosterone level decreased as a result of increased sex hormone binding globulin.
1(0,0,0,1) Details