Protein Information

Name lactate dehydrogenase (protein family or complex)
Synonyms LDH; lactate dehydrogenase; lactate dehydrogenases

Compound Information

Name aldrin
CAS

Reference List

PubMed Abstract RScore(About this table)
2282077 Joseph KV, Rao KJ: Aldrin toxicity on amphibian neuronal, hepatic and muscular tissue oxidative enzymes. Biochem Int. 1990 Oct;22(1):173-7.

It was observed that sublethal concentration of aldrin inhibited the activities of SDH, MDH and ICDH while it elevated the activities of LDH and G-6-PDH.
81(1,1,1,1) Details
1830481 Reddy MS, Rao KV: Tissue glycolytic potentials of penaeid prawn, Metapenaeus monoceros during methylparathion, carbaryl and aldrin exposure. Biochem Int. 1991 Jan;23(2):367-75.

The decrease in the lactate dehydrogenase activity levels and an increase in the lactate content indicative of reduced mobilization of pyruvate into the citric acid cycle.
1(0,0,0,1) Details
11701388 Bayoumi AE, Garcia-Fernandez AJ, Ordonez C, Perez-Pertejo Y, Cubria JC, Reguera RM, Balana-Fouce R, Ordonez D: Cyclodiene organochlorine insecticide-induced alterations in the sulfur-redox cycle in CHO-K1 cells. Comp Biochem Physiol C Toxicol Pharmacol. 2001 Nov;130(3):315-23.

The effect of the cyclodiene organochlorine pesticides aldrin, dieldrin and endosulfan was assessed on CHO-K1 cultures at fractions of their lethal doses, determined by the neutral red (NRI) incorporation assay (NRI6.25, NRI12.5 and NRI25).
Changes in cell membrane integrity were assessed by the lactate dehydrogenase (LDH) release assay and lipid peroxidation for a wide range of pesticide concentrations.
1(0,0,0,1) Details
2426844 Trela BA, Carlson GP, Chadwick RW, Copeland MF: A comparison of in vitro and in vivo methods for evaluating alterations in hepatic drug metabolism following mercuric chloride administration. Toxicol Lett. 1986 Jul-Aug;32(1-2):133-40.


The activities of ethylmorphine demethylase, hexobarbital oxidase and aldrin epoxidase determined in vitro were not inhibited by mercuric chloride although aniline hydroxylase activity was decreased.
0(0,0,0,0) Details