Protein Information

Name cholinesterases
Synonyms Acylcholine acylhydrolase; BCHE; BCHE protein; Butyrylcholine esterase; Butyrylcholinesterase; CHE1; Choline esterase II; Cholinesterase…

Compound Information

Name aldrin
CAS

Reference List

PubMed Abstract RScore(About this table)
740517 Wegman RC, Greve PA: Organochlorines, cholinesterase inhibitors, and aromatic amines in Dutch water samples, September 1969--December 1975. Pestic Monit J. 1978 Dec;12(3):149-62.

Other organochlorine pesticides and their metabolites, heptachlor, heptachlor epoxide, aldrin, dieldrin, endrin alpha- and beta-endosulfan, and sigmaDDT were detected occasionally, but only in low concentrations.
3(0,0,0,3) Details
6777420 Basol MS, Eren S, Sadar MH: Comparative toxicity of some pesticides on human health and some aquatic species. J Environ Sci Health B. 1980;15(6):993-1004.

Inhibition studies have been carried on the hydrolysis reactions catalyzed by cholinesterases taken from electric eel, human and horse serums by Sevin, Aldrin and Malathion.
32(0,1,1,2) Details
13304690 HALEY TJ: The insecticides; their hazard in industry and in the home. Calif Med. 1956 Apr;84(4):258-64.

Organic phosphates destroy cholinesterase and produce effects related to overstimulation of the cholinergic branch of the autonomic nervous system.
These compounds may be grouped in the following order of decreasing toxicity: TEPP, HETP, parathion, OMPA, ENP, aldrin, chlorophenothane, toxaphene, gamma benzene hexachloride, malathon and chlordane.
1(0,0,0,1) Details
8326087 Chaturvedi AK: Toxicological evaluation of mixtures of ten widely used pesticides. J Appl Toxicol. 1993 May-Jun;13(3):183-8.

Mice were given four mixtures of alachlor, aldrin, atrazine, 2,4-dichlorophenoxyacetic acid, DDT, dieldrin, endosulfan, lindane, parathion and toxaphene, at 0.01, 0.1, 1.0 and 10 ppm of each of these pesticides, in drinking water for 90 days ad libitum.
The serum cholinesterase activity was inhibited by ca. 50% in the 2.5 and 5 mg kg-1 groups on either one or both of Days 8 and 15; the liver/body weight ratio increased by 24-79% and the pentobarbital-induced sleep time decreased by 80-96%.(ABSTRACT TRUNCATED AT 250 WORDS)
1(0,0,0,1) Details