| Name | debrisoquine 4 hydroxylase |
|---|---|
| Synonyms | CPD 6; Xenobiotic monooxygenase; Microsomal monooxygenase; Flavoprotein linked monooxygenase; CPD6; CYP2D; CYP2D variant; CYP2D6… |
| Name | aldrin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 3577206 | Guengerich FP, Umbenhauer DR, Churchill PF, Beaune PH, Bocker R, Knodell RG, Martin MV, Lloyd RS: Polymorphism of human cytochrome P-450. . Xenobiotica. 1987 Mar;17(3):311-6. Reconstitution and immunochemical studies establish that the following reactions are catalysed by the individual P-450s--P-450DB: debrisoquine 4-hydroxylation, sparteine delta 5-oxidation, bufuralol 1'-hydroxylation, encainide O-demethylation, and 4-hydroxylation; P-450PA: phenacetin O-deethylation; P-450MP: S-mephenytoin 4-hydroxylation and methyl hydroxylation; P-450NF: oxidation of nifedipine and 16 other substituted dihydropyridines, 2- and 4-hydroxylation, aldrin epoxidation, benzphetamine N-demethylation and 6 beta-hydroxylation of and Studies with this probe establish that the sex and strain variation in debrisoquine 4-hydroxylase and related activities is related to differences in the levels of a 2.0 kb length mRNA present.(ABSTRACT TRUNCATED AT 250 WORDS) |
1(0,0,0,1) | Details |
| 4027115 | Boobis AR, Hampden CE, Murray S, Beaune P, Davies DS: Attempts to phenotype human liver samples in vitro for debrisoquine 4-hydroxylase activity. Br J Clin Pharmacol. 1985 Jun;19(6):721-9. Evidence is presented here and elsewhere that bufuralol 1'-hydroxylase and debrisoquine 4-hydroxylase are activities catalysed by the same form of cytochrome P-450 in man, and that this form is different from that catalysing the epoxidation of aldrin. |
38(0,1,2,3) | Details |