| Name | aryl hydrocarbon hydroxylase |
|---|---|
| Synonyms | Aryl hydrocarbon hydroxylase; Flavoprotein linked monooxygenase; Xenobiotic monooxygenase; Microsomal monooxygenase; CP37; CYP3A7; CYPIIIA 7; CYPIIIA7… |
| Name | aldrin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8332081 | Kulka U, Paul D, Bauchinger M: Development of short-term mutagenicity test systems in vitro: metabolic activation of indirectly acting mutagens by three immortal rat hepatocyte lines. Mutagenesis. 1993 May;8(3):193-7. Furthermore, activities of the two enzymes aryl hydrocarbon hydroxylase and aldrin-epoxidase, which play major roles in the cytochrome P450-dependent metabolism, could be determined in all cell lines. |
31(0,1,1,1) | Details |
| 2508517 | Banton MI, Flory W, Jowett PL, Winston GW: Comparison of the effects of Sesbania drummondii on the hepatic microsomal monooxygenase systems of chickens and rats. Am J Vet Res. 1989 Oct;50(10):1795-9. Increases of twofold in the cytochrome P-450 content, -cytochrome c-reductase, aminopyrine-N-demethylase, hydroxylase, ethoxycoumarin-O-deethylase, and aryl hydrocarbon hydroxylase activities; fourfold in the aldrin epoxidase activity; and 15-fold in the ethoxyresorufin-O-deethylase activity were observed in the S drummondii-treated chickens. |
6(0,0,1,1) | Details |
| 6894731 | Kremers P, Goujon F, De Graeve J, Van Cantfort J, Gielen JE: Multiplicity of cytochrome P-450 in primary fetal hepatocytes in culture. Eur J Biochem. 1981 May;116(1):67-72. We have examined the effect of dexamethasone on the cytochrome P-450 type supporting different enzymic activities (aryl hydrocarbon hydroxylase, ethoxycoumarin deethylase, aldrin monooxygenase). |
6(0,0,1,1) | Details |
| 6096035 | Wiebel FJ, Kiefer F, Murdia US: Phenobarbital induces cytochrome P-450- and cytochrome P-448-dependent monooxygenases in rat hepatoma cells. Chem Biol Interact. 1984 Dec;52(2):151-62. The induction by phenobarbital (PB) of aldrin epoxidase (AE) and aryl hydrocarbon hydroxylase (AHH), markers of cytochrome P-450- and cytochrome P-448-dependent monooxygenases, was studied in cell lines derived from Reuber H35 rat hepatoma which differ widely in their degree of differentiation. |
6(0,0,1,1) | Details |
| 1907123 | Skaare JU, Jensen EG, Goksoyr A, Egaas E: Response of xenobiotic metabolizing enzymes of rainbow trout (Oncorhynchus mykiss) to the mono-ortho substituted polychlorinated PCB congener 2,3',4,4',5-pentachlorobiphenyl, PCB-118, detected by enzyme activities and immunochemical methods. Arch Environ Contam Toxicol. 1991 Apr;20(3):349-52. In liver microsomes prepared from fish killed 4 days after administration, the cytochrome P450-dependent monooxygenase activities of 7-ethoxyresorufin O-deethylase (EROD), aryl hydrocarbon hydroxylase (AHH), and aldrin epoxidase (AE) were measured. |
6(0,0,1,1) | Details |
| 1215658 | Bellward GD, Dawson R, Otten M: The effect of dieldrin-contaminated feed on rat hepatic microsomal epoxide hydrase and aryl hydrocarbon hydroxylase. Res Commun Chem Pathol Pharmacol. 1975 Dec;12(4):669-84. Two days of intraperitoneal administration of technical grade dieldrin, analytical grade dieldrin and analytical grade aldrin gave similar increases in EH activity within this group. |
1(0,0,0,1) | Details |
| 2043048 | Misra RR, Lorr NA, Bloom SE: Cyclophosphamide metabolism in the primary immune organs of the chick: assays of drug activation, P450 expression, and aldehyde dehydrogenase. Arch Toxicol. 1991;65(1):32-8. Aldrin epoxidase (AE) was used to detect phenobarbital (PB)-inducible P450 activity. Ethoxyresorufin-O-deethylase (EROD) and aryl hydrocarbon hydroxylase (AHH) were used for the evaluation of polycyclic aromatic hydrocarbon (PAH)-inducible P450 activities in control and PB- or 3,3',4,4'-tetrachlorobiphenyl (TCB)-induced animals. |
1(0,0,0,1) | Details |
| 817422 | Vainio H, Parkki MG: Enhancement of microsomal monooxygenase, epoxide hydrase and UDPglucuronyltransferase by aldrin, dieldrin and isosafrole administrations in rat liver. Toxicology. 1976 Mar;5(3):279-86. All the compounds studied were found to enhance the activities of microsomal monooxygenase (e.g. p-nitroanisole O-demethylase, aryl hydrocarbon hydroxylase), epoxide hydrase (styrene oxide as substrate) and UDPglucuronyltransferase as aglycone). |
1(0,0,0,1) | Details |
| 6692492 | Cresteil T, Goujon-Letawe F, Le Provost E, Kremers P, Lesca P: Induction by 9-hydroxyellipticine of aryl hydrocarbon hydroxylase in perinatal rat liver and in primary fetal hepatocytes in culture. Chem Biol Interact. 1984 Jan;48(1):103-13. In neonatal and, to a lesser extent, in fetal rat liver, 9-hydroxyellipticine was able to promote the induction of cytochrome P-450, supporting especially aryl hydrocarbon hydroxylase (AHH) but not aldrin epoxidase activity. |
1(0,0,0,1) | Details |
| 6414484 | Denomme MA, Bandiera S, Lambert I, Copp L, Safe L, Safe S: Polychlorinated biphenyls as phenobarbitone-type inducers of microsomal enzymes. Biochem Pharmacol. 1983 Oct 1;32(19):2955-63. This study examines the effects of structure on the activity of a series of 2,4-dichloro-substituted biphenyls as inducers of several microsomal enzyme activities including dimethylaminoantipyrine N-demethylase, benzo [a] pyrene hydroxylase, aldrin epoxidase, and ethoxyresorufin O-deethylase. |
0(0,0,0,0) | Details |
| 3107167 | Azais V, Arand M, Rauch P, Schramm H, Bellenand P, Narbonne JF, Oesch F, Pascal G, Robertson LW: A time-course investigation of levels and drug metabolizing enzyme activities in rats following a single treatment with prototypic polychlorinated biphenyls and DDT. Toxicology. 1987 Jun;44(3):341-54. Although 3,3',4,4'-tetrachlorobiphenyl specifically induced certain drug-metabolizing enzyme activities, e.g. aryl hydrocarbon hydroxylase and UDP-glucuronosyltransferase (toward no highly significant correlations were found among the levels and drug-metabolizing enzyme activities in the liver (aminopyrine N-demethylase, aryl hydrocarbon hydroxylase, aldrin epoxidase, microsomal epoxide hydrolase, UDP-glucuronosyltransferase toward glutathione transferase toward 1-chloro-2,4-dinitrobenzene and cytochrome P-450 content) as determined by multiple linear regression analysis. |
0(0,0,0,0) | Details |
| 3004505 | Falzon M, McMahon JB, Schuller HM: Xenobiotic-metabolizing enzyme activity in human non-small-cell derived lung cancer cell lines. Biochem Pharmacol. 1986 Feb 15;35(4):563-8. No aldrin epoxidase activity was present in either untreated or pretreated cell lines. |
0(0,0,0,0) | Details |
| 6603386 | Meier PJ, Mueller HK, Dick B, Meyer UA: Hepatic monooxygenase activities in subjects with a genetic defect in drug oxidation. Gastroenterology. 1983 Sep;85(3):682-92. There was no correlation between the capacity for debrisoquine hydroxylation and the total concentration of microsomal cytochrome P450, cytochrome b5, or the activities of -cytochrome c reductase, aminopyrine-N-demethylase, aryl hydrocarbon hydroxylase, ethoxycoumarin-O-deethylase, aldrin epoxidase, and 2-biphenylhydroxylase. |
0(0,0,0,0) | Details |