Protein Information

Name cytochrome P450 monooxygenases
Synonyms CYP M; CYP20A1; CYP20A1 protein; Cytochrome P450 family 20 subfamily A polypeptide 1; Cytochrome P450 monooxygenase; CYP20A1 proteins; Cytochrome P450 family 20 subfamily A polypeptide 1s; Cytochrome P450 monooxygenases

Compound Information

Name aldrin
CAS

Reference List

PubMed Abstract RScore(About this table)
1375920 Foster JR, Green T, Smith LL, Lewis RW, Hext PM, Wyatt I: Methylene chloride--an inhalation study to investigate pathological and biochemical events occurring in the lungs of mice over an exposure period of 90 days. Fundam Appl Toxicol. 1992 Apr;18(3):376-88.

The appearance and disappearance of the lesion in the Clara cell correlated well with the activity of cytochrome P450 monooxygenase in the Clara cell as assessed immunocytochemically (cytochromes P450IIB 1 and 2) in the whole lung and biochemically in the freshly isolated Clara cell (determined by ethoxycoumarin O-dealkylation and aldrin epoxidation).
31(0,1,1,1) Details
20050562 Xiao NW, Liu XH, Li W, Ge F: Effect of herbicide acetochlor on cytochrome P450 monooxygenases and GST of earthworms Eisenia fetida. J Environ Sci. 2006;18(1):135-40.

Effects of the acetochlor on cytochrome P450 monooxygenases p-nitroanisole O-demethylase (ODM), aldrin epoxidase (AE) and glutathione-S-transferases (GSTs) activities were determined.
8(0,0,1,3) Details
9076527 Kotze AC: Cytochrome P450 monooxygenase activity in Haemonchus contortus (Nematoda). Int J Parasitol. 1997 Jan;27(1):33-40.

Cytochrome P450 monooxygenase activities towards aldrin and 7-ethoxycoumarin were detected in microsomes prepared from L1 and L3 larvae of Haemonchus contortus, and very low levels of activity towards aldrin were detected in adults.
8(0,0,1,3) Details
14503602 Qiu X, Li W, Tian Y, Leng X: Cytochrome P450 monooxygenases in the cotton bollworm (Lepidoptera: Noctuidae): tissue difference and induction. J Econ Entomol. 2003 Aug;96(4):1283-9.

Orthogonal array design was used to establish the optimal conditions for measuring Aldrin epoxidation (AE).
1(0,0,0,1) Details
18432628 Krieger RI: Aldrin epoxidation and dihydroisodrin hydroxylation as probes of in vivo and in vitro oxidative metabolic capability of some caterpillars. Pest Manag Sci. 2008 Jun;64(6):622-7.

Localization of relatively high concentrations of these cytochrome P450 monooxygenases in gut tissue of lepidoptera may represent an important means to minimize absorption of lipophilic foreign chemicals in food.
1(0,0,0,1) Details
18065401 Rupasinghe SG, Wen Z, Chiu TL, Schuler MA: Helicoverpa zea CYP6B8 and CYP321A1: different molecular solutions to the problem of metabolizing plant toxins and insecticides. Protein Eng Des Sel. 2007 Dec;20(12):615-24. Epub 2007 Dec 6.

Under continual exposure to naturally occurring plant toxins and synthetic insecticides, insects have evolved cytochrome P450 monooxygenases (P450s) capable of metabolizing a wide range of structurally different compounds.
The metabolic profiles for several plant toxins (xanthotoxin, angelicin) and insecticides (cypermethrin, aldrin and diazinon) correlate well with these predictive models.
1(0,0,0,1) Details
11425027 Lee SE, Lees EM: Biochemical mechanisms of resistance in strains of Oryzaephilus surinamensis (Coleoptera: Silvanidae) resistant to malathion and chlorpyrifos-methyl. J Econ Entomol. 2001 Jun;94(3):706-13.

Cytochrome P450 monooxygenase activity was based on cytochrome P450 content, aldrin epoxidase activity, and oxidation of organophosphate insecticides, all elevated in resistant strains.
32(0,1,1,2) Details