| Name | P 450MP |
|---|---|
| Synonyms | (R) limonene 6 monooxygenase; Xenobiotic monooxygenase; Mephenytoin 4 hydroxylase; Microsomal monooxygenase; S mephenytoin 4 hydroxylase; (S) limonene 6 monooxygenase; (S) limonene 7 monooxygenase; CPC 9… |
| Name | aldrin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 3577206 | Guengerich FP, Umbenhauer DR, Churchill PF, Beaune PH, Bocker R, Knodell RG, Martin MV, Lloyd RS: Polymorphism of human cytochrome P-450. . Xenobiotica. 1987 Mar;17(3):311-6. Reconstitution and immunochemical studies establish that the following reactions are catalysed by the individual P-450s--P-450DB: debrisoquine 4-hydroxylation, sparteine delta 5-oxidation, bufuralol 1'-hydroxylation, encainide O-demethylation, and 4-hydroxylation; P-450PA: phenacetin O-deethylation; P-450MP: S-mephenytoin 4-hydroxylation and methyl hydroxylation; P-450NF: oxidation of nifedipine and 16 other substituted dihydropyridines, 2- and 4-hydroxylation, aldrin epoxidation, benzphetamine N-demethylation and 6 beta-hydroxylation of and |
33(0,1,1,3) | Details |
| 10375008 | McKillop D, Back DJ, McCormick AD, Evans JA, Tjia J: Preclinical and in vitro assessment of the potential of D0870, an antifungal agent, for producing clinical drug interactions. Xenobiotica. 1999 Apr;29(4):395-408. D0870, an azole antifungal agent, produced dose-related increases in total cytochrome P450 and aldrin epoxidase when administered as 14 daily oral doses (0, 0.5, 2.5 and 12.5 mg/kg/day) to the male rat. In human hepatic microsomal incubations, D0870 produced pronounced inhibition of CYP2C9 hydroxylase) and, to a lesser degree, CYP3A4 6beta-hydroxylase), but had more limited effects on CYP1A2, 2C19 and 2D6 activity. |
3(0,0,0,3) | Details |
| 3748010 | Guengerich FP, Muller-Enoch D, Blair IA: Oxidation of quinidine by human liver cytochrome P-450. . Mol Pharmacol. 1986 Sep;30(3):287-95. The substrate specificity of human P-450NF is discussed further in terms of its regioselective oxidations of complex molecules including quinidine, aldrin, benzphetamine, and and several 2,6-dimethyl-1,4-dihydropyridines. |
0(0,0,0,0) | Details |