| Name | epoxide hydrolase |
|---|---|
| Synonyms | EPHX; EPHX 1; EPHX1; EPHX1 protein; EPOX; Epoxide hydratase; Epoxide hydrolase; Epoxide hydrolase 1… |
| Name | aldrin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 3818484 | Wisniewski JA, Moody DE, Hammock BD, Shull LR: Interlobular distribution of hepatic xenobiotic-metabolizing enzyme activities in cattle, goats and sheep. J Anim Sci. 1987 Jan;64(1):210-5. Within individual species, concentrations of cytochrome P-450 and b5 and activities of cytochrome c reductase, aldrin epoxidase, aminopyrine N-demethylase, ethoxycoumarin O-deethylase, microsomal and cytosolic stilbene oxide (epoxide) hydrolase and glutathione S-transferase were not different (P greater than .05) among the various hepatic lobes. |
0(0,0,0,0) | Details |
| 3390215 | Leslie C, Reidy GF, Murray M, Stacey NH: Induction of xenobiotic biotransformation by the insecticide chlordimeform, a metabolite 4-chloro-o-toluidine and a structurally related chemical o-toluidine. Biochem Pharmacol. 1988 Jul 1;37(13):2529-35. The metabolite 4-chloro-o-toluidine increased cytochrome P-450, ethoxyresorufin-O-deethylase, ethoxycoumarin-O-deethylase, glutathione S-transferase and epoxide hydrolase activities. o-Toluidine induced cytochrome P-450, ethoxyresorufin-O-deethylase, ethoxycoumarin-O-deethylase, and aldrin epoxidase activities. |
32(0,1,1,2) | Details |
| 6334986 | Woodhouse KW, Mutch E, Williams FM, Rawlins MD, James OF: The effect of age on pathways of drug metabolism in human liver. . Age Ageing. 1984 Nov;13(6):328-34. Five parameters were investigated: two microsomal mono-oxygenases; aldrin epoxidation and 7-ethoxycoumarin-O-de-ethylation; microsomal protein recovery; epoxide hydrolase activity and concentrations of reduced gluthatione. |
31(0,1,1,1) | Details |
| 6603231 | Woodhouse KW, Williams FM, Mutch E, Wright P, James OF, Rawlins MD: The effect of alcoholic cirrhosis on the activities of microsomal aldrin epoxidase, 7-ethoxycoumarin O-de-ethylase and epoxide hydrolase, and on the concentrations of in human liver. Br J Clin Pharmacol. 1983 Jun;15(6):667-72. |
12(0,0,2,2) | Details |
| 2619326 | Leslie C, Reidy GF, Stacey NH: Effect of ofurace, oxadixyl, and alachlor on xenobiotic biotransformation in the rat liver. Arch Environ Contam Toxicol. 1989 Nov;18(6):876-80. It left ethoxyresorufin-O-deethylase, aldrin epoxidase and epoxide hydrolase activities unchanged and decreased p-hydroxylase activities. |
6(0,0,1,1) | Details |
| 15167984 | Perrone CE, Ahr HJ, Duan JD, Jeffrey AM, Schmidt U, Williams GM, Enzmann HH: Embryonic turkey liver: activities of biotransformation enzymes and activation of DNA-reactive carcinogens. Arch Toxicol. 2004 Oct;78(10):589-98. Epub 2004 May 28. Biochemical analyses of 22-day in ovo turkey liver post-mitochondrial fractions revealed activities of the biotransformation enzymes 7-ethoxycoumarin de-ethylase (ECOD), 7-ethoxyresorufin de-ethylase (EROD), aldrin epoxidase (ALD), epoxide hydrolase (EH), glutathione S-transferase (GST), and UDP-glucuronyltransferase |
6(0,0,1,1) | Details |
| 9137805 | Rogiers V, Vandenberghe Y, Vanhaecke T, Geerts A, Callaerts A, Carleer J, Roba J, Vercruysse A: Observation of hepatotoxic effects of 2-n-pentylaminoacetamide (Milacemide) in rat liver by a combined in vivo/in vitro approach. Arch Toxicol. 1997;71(5):271-82. The xenobiotic biotransformation capacity of the isolated hepatocytes was studied by measuring the cytochrome P450 content, ethoxycoumarin-O-deethylase (ECOD), pentoxyresorufin-O-deethylase (PROD), ethoxyresorufin-O-deethylase (EROD), aldrin epoxidase (AE), epoxide hydrolase (EH) and glutathione S-transferase (GST) enzyme activities. |
6(0,0,1,1) | Details |
| 8471063 | Borlakoglu JT, Scott A, Henderson CJ, Jenke HJ, Wolf CR: Transplacental transfer of polychlorinated biphenyls induces simultaneously the expression of P450 isoenzymes and the protooncogenes c-Ha-ras and c-raf. Biochem Pharmacol. 1993 Apr 6;45(7):1373-86. Concomitantly, the metabolism of nitroanisole, ethoxyresorufin and benzo [a] pyrene was significantly increased, but foetal metabolism of dimethylnitrosamine was not detectable and only marginal increases in the metabolism of aminopyrine and aldrin were seen. Further measurements show significant increases in foetal and maternal epoxide hydrolase, glutathione-S-transferase and UDP-glucuronyl transferase activities, thus suggesting that treatment with Aroclor 1254 resulted in coordinated increases in foetal and maternal oxidative and post-oxidative drug metabolism. |
1(0,0,0,1) | Details |
| 9928623 | Bomhard EM, Schmidt U, Loser E: Time course of enzyme induction in liver and kidneys and absorption, distribution and elimination of 1,4-dichlorobenzene in rats. Toxicology. 1998 Nov 16;131(2-3):73-91. The monoxygenases 7-ethoxycoumarin O-deethylase (ECOD), 7-ethoxyresorufin O-deethylase (EROD) and aldrin epoxidase (ALD) as well as the phase II enzymes; epoxide hydrolase (EH), glutathione S-transferase (GS-T) and glucuronyl transferase (GLU-T) were dose-dependently induced in the liver of males and females. |
6(0,0,1,1) | Details |
| 10418972 | de Sousa G, Nicolas F, Placidi M, Rahmani R, Benicourt M, Vannier B, Lorenzon G, Mertens K, Coecke S, Callaerts A, Rogiers V, Khan S, Roberts P, Skett P, Fautrel A, Chesne C, Guillouzo A: A multi-laboratory evaluation of cryopreserved monkey hepatocyte functions for use in pharmaco-toxicology. Chem Biol Interact. 1999 Jun 1;121(1):77-97. After thawing, Phase I and Phase II activities (cytochrome P450, ethoxycoumarin-O-deethylase, aldrin epoxidase, epoxide hydrolase, glutathione transferase, glutathione reductase and peroxidase) were well preserved. |
6(0,0,1,1) | Details |
| 2890477 | Peakall DB, Jeffrey DA, Boersma D: Mixed-function oxidase activity in seabirds and its relationship to oil pollution. Comp Biochem Physiol C. 1987;88(1):151-4. The hepatic activity of epoxide hydrolase, aldrin epoxidase, aminopyrine N-demethylase, 7-ethoxyresorufin O-deethylase, benzo (a) pyrene 3-hydroxylase and UDP glucuronyl transferase was determined in adult herring gulls (Larus argentatus) at various stages of the breeding season. 2. |
6(0,0,1,1) | Details |
| 3107167 | Azais V, Arand M, Rauch P, Schramm H, Bellenand P, Narbonne JF, Oesch F, Pascal G, Robertson LW: A time-course investigation of levels and drug metabolizing enzyme activities in rats following a single treatment with prototypic polychlorinated biphenyls and DDT. Toxicology. 1987 Jun;44(3):341-54. Although 3,3',4,4'-tetrachlorobiphenyl specifically induced certain drug-metabolizing enzyme activities, e.g. aryl hydrocarbon hydroxylase and UDP-glucuronosyltransferase (toward no highly significant correlations were found among the levels and drug-metabolizing enzyme activities in the liver (aminopyrine N-demethylase, aryl hydrocarbon hydroxylase, aldrin epoxidase, microsomal epoxide hydrolase, UDP-glucuronosyltransferase toward glutathione transferase toward 1-chloro-2,4-dinitrobenzene and cytochrome P-450 content) as determined by multiple linear regression analysis. |
0(0,0,0,0) | Details |
| 2411555 | Cresteil T, Beaune P, Kremers P, Celier C, Guengerich FP, Leroux JP: Immunoquantification of epoxide hydrolase and cytochrome P-450 isozymes in fetal and adult human liver microsomes. Eur J Biochem. 1985 Sep 2;151(2):345-50. Aldrin epoxidase and benzphetamine-N-demethylase activities were correlated with isozyme 5 concentration, but with different slopes for adult and fetal microsomes: adult preparations catalyzed these two reactions more efficiently. |
3(0,0,0,3) | Details |
| 3629631 | Reidy GF, Rose HA, Stacey NH: Effect of length of exposure to malathion on xenobiotic biotransformation in male rat liver. Toxicol Lett. 1987 Sep;38(1-2):193-9. Groups of rats dosed i.p. daily for 1 or 2 weeks with 40 or 200 mg/kg malathion showed an increase in epoxide hydrolase activity (1 week, 200 mg/kg) and glutathione S-transferase activity (1 week, 200 mg/kg; 2 weeks 40 and 200 mg/kg). Aldrin epoxidation was decreased after 1 week of exposure to 200 mg/kg and by both dosage regimens after 2 weeks. |
2(0,0,0,2) | Details |
| 2882937 | Walker CH, Newton I, Hallam SD, Ronis MJ: Activities and toxicological significance of hepatic microsomal enzymes of the kestrel (Falco tinnunculus) and sparrowhawk (Accipiter nisus). Comp Biochem Physiol C. 1987;86(2):379-82. Activities of hepatic microsomal monooxygenase and epoxide hydrolase in sparrowhawks and kestrels were determined using organochlorine substrates. |
2(0,0,0,2) | Details |
| 12542283 | Xu D, Zhong W, Deng L, Chai Z, Mao X: Levels of extractable organohalogens in pine needles in China. Environ Sci Technol. 2003 Jan 1;37(1):1-6. The relative proportions of the known organochlorines (such as HCHs, DDTs, aldrin, heptachlor, and chlordanes) to total EOCl and EPOCl were 0.3-5.2% and 1.4-19.8%, respectively, which implied that a major portion of the EPOCl measured in pine needles was unknown. The EPOX accumulation rates were preliminarily estimated under the natural condition, which suggested that the "young" needle accumulated EPOX more quickly than the "old" and more than 94% of EPOX was accumulated at the first year of pine needles. |
1(0,0,0,1) | Details |
| 6149883 | Mullin CA, Matsumura F, Croft BA: Epoxide forming and degrading enzymes in the spider mite, Tetranychus urticae. Comp Biochem Physiol C. 1984;79(1):85-92. Epoxidation of aldrin was primarily microsomal, required was associated with a -cytochrome c reductase, and was inhibited by CO, 1-phenylimidazole and piperonyl butoxide. Trans- and cis-epoxide hydrolases resided mostly in the microsomal fraction but were localized also in the cytosol. |
1(0,0,0,1) | Details |
| 8288035 | Borlakoglu JT, Scott A, Henderson CJ, Wolf CR: Expression of P450 isoenzymes during rat liver organogenesis. Int J Biochem. 1993 Nov;25(11):1659-68. Monooxygenase activities were not measurable at day 10 of gestation, but shortly before birth (day 20 of gestation) and thereafter a surge in monooxygenase activities was observed using ethoxyresorufin, nitroanisole, aminopyrine, dimethylnitrosamine and aldrin as substrates. 3. In contrast, as early as day 10 of gestation, post oxidative drug metabolism was measurable, when assessed for reactions catalysed by UDP-glucuronyltransferase, glutathione S-transferase and epoxide hydrolase. 4. |
1(0,0,0,1) | Details |
| 2104995 | Schoket B, Vincze I: Dose-related induction of rat hepatic drug-metabolizing enzymes by diuron and chlorotoluron, two substituted phenylurea herbicides. Toxicol Lett. 1990 Jan;50(1):1-7. Induction of epoxide hydrolase, -glucuronyltransferase and glutathione S-transferases also shows saturation curves in the function of molar doses. |
1(0,0,0,1) | Details |
| 8347134 | Borlakoglu JT, Scott A, Henderson CJ, Wolf CR: Alterations in rat hepatic drug metabolism during pregnancy and lactation. Biochem Pharmacol. 1993 Jul 6;46(1):29-36. Within this time period the N-demethylation of aminopyrine, the rate of aldrin epoxidation and the N-demethylation of demethylnitrosamine was reduced by 53, 74 and 21%, respectively. Furthermore, the activities of UDP-glucuronyltransferase and glutathione S-transferase were increased by 21 and 27%, but those of epoxide hydrolase were reduced by 85%. |
1(0,0,0,1) | Details |
| 3004505 | Falzon M, McMahon JB, Schuller HM: Xenobiotic-metabolizing enzyme activity in human non-small-cell derived lung cancer cell lines. Biochem Pharmacol. 1986 Feb 15;35(4):563-8. No aldrin epoxidase activity was present in either untreated or pretreated cell lines. Untreated NCI-H322 and NCI-H358 also contained cytochrome b5, cytochrome c reductase and epoxide hydrolase activities. |
1(0,0,0,1) | Details |