| Name | Microsomal monooxygenase |
|---|---|
| Synonyms | ARO; Microsomal monooxygenase; Flavoprotein linked monooxygenase; ARO 1; ARO1; Aromatase; Aromatase cytochrome P450; CPV 1… |
| Name | aldrin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15091496 | Fossi MC, Massi A, Lari L, Marsili L, Focardi S, Leonzio C, Renzoni A: Interspecies differences in mixed function oxidase activity in birds: Relationship between feeding habits, detoxication activities and organochlorine accumulation. Environ Pollut. 1995;90(1):15-24. The following liver microsomal monooxygenase activities were measured: aldrin epoxidase, ethoxyresorufin dealkylation (EROD), benzyloxyresorufin dealkylation (BROD) and pentoxyresorufin dealkylation (PROD). |
31(0,1,1,1) | Details |
| 817422 | Vainio H, Parkki MG: Enhancement of microsomal monooxygenase, epoxide hydrase and UDPglucuronyltransferase by aldrin, dieldrin and isosafrole administrations in rat liver. Toxicology. 1976 Mar;5(3):279-86. |
7(0,0,1,2) | Details |
| 16996190 | Laville N, Balaguer P, Brion F, Hinfray N, Casellas C, Porcher JM, Ait-Aissa S: Modulation of aromatase activity and mRNA by various selected pesticides in the human choriocarcinoma JEG-3 cell line. Toxicology. 2006 Nov 10;228(1):98-108. Epub 2006 Aug 24. To further investigate the mechanisms of aromatase induction we measured CYP19 mRNA expression and showed that methoxychlor, aldrin, chlordane and tributyltin induced the transcription of the cyp19 gene. |
6(0,0,1,1) | Details |
| 15091443 | Johnston G, Dawson A, Walker CH: Effects of prochloraz and malathion on the red-legged partridge: a semi-natural field study. Environ Pollut. 1996;91(2):217-25. Cytochrome P-450, aldrin epoxidase and 7-ethoxyresorufin-O-deethylase (EROD) activities were found to be significantly higher in the group exposed to prochloraz alone compared to controls, suggesting that induction of the hepatic microsomal monooxygenase system had occurred by ingestion of prochloraz-treated wheat. |
6(0,0,1,1) | Details |
| 2508517 | Banton MI, Flory W, Jowett PL, Winston GW: Comparison of the effects of Sesbania drummondii on the hepatic microsomal monooxygenase systems of chickens and rats. Am J Vet Res. 1989 Oct;50(10):1795-9. Increases of twofold in the cytochrome P-450 content, -cytochrome c-reductase, aminopyrine-N-demethylase, hydroxylase, ethoxycoumarin-O-deethylase, and aryl hydrocarbon hydroxylase activities; fourfold in the aldrin epoxidase activity; and 15-fold in the ethoxyresorufin-O-deethylase activity were observed in the S drummondii-treated chickens. |
4(0,0,0,4) | Details |
| 2386543 | Matthew DE, Houston JB: Drug metabolizing capacity in vitro and in vivo--I. Biochem Pharmacol. 1990 Aug 15;40(4):743-9. Correlations between hepatic microsomal monooxygenase markers in beta-naphthoflavone-induced rats.. No trends were observed with the formation clearance of 3-hydroxymethylantipyrine and 7-methoxycoumarin O-demethylase whilst a negative response was observed with aldrin epoxidase. |
3(0,0,0,3) | Details |
| 2386544 | Matthew DE, Houston JB: Drug metabolizing capacity in vitro and in vivo--II. Biochem Pharmacol. 1990 Aug 15;40(4):751-8. Correlations between hepatic microsomal monooxygenase markers in phenobarbital-induced rats.. The in vivo clearance of (TOL), (TH), antipyrine (AP) and its metabolites were determined in the same rats used for hepatic microsome preparation and assessment of P450 content and activities (via 7-ethoxycoumarin O-deethylase (ECOD), 7 ethoxyresorufin O-deethylase, 7-methoxycoumarin O-demethylase (MCOD) and aldrin epoxidase determinations). |
2(0,0,0,2) | Details |
| 2866919 | Ronis MJ, Walker CH: Species variations in the metabolism of liposoluble organochlorine compounds by hepatic microsomal monooxygenase: comparative kinetics in four vertebrate species. Comp Biochem Physiol C. 1985;82(2):445-9. Lineweaver-Burk plots gave straight lines for both aldrin (HHDN) and the dieldrin analogue HCE. |
1(0,0,0,1) | Details |
| 2882937 | Walker CH, Newton I, Hallam SD, Ronis MJ: Activities and toxicological significance of hepatic microsomal enzymes of the kestrel (Falco tinnunculus) and sparrowhawk (Accipiter nisus). Comp Biochem Physiol C. 1987;86(2):379-82. Activities of hepatic microsomal monooxygenase and epoxide hydrolase in sparrowhawks and kestrels were determined using organochlorine substrates. |
1(0,0,0,1) | Details |
| 4052094 | Kelley M, Lambert I, Merrill J, Safe S: 1,4-Bis [2-(3,5-dichloropyridyloxy)] (TCPOBOP) and related compounds as inducers of hepatic monooxygenases. Biochem Pharmacol. 1985 Oct 1;34(19):3489-94. The results confirm the microsomal monooxygenase enzyme induction activity of TCPOBOP, and the observed structure-dependent potencies of several related homologs support a receptor-mediated mechanism of action for the process. Dose-response induction of mice hepatic microsomal cytochrome P-450, aldrin epoxidase and dimethylaminoantipyrine N-demethylase gave ED50 values for TCPOBOP and five homologs. |
1(0,0,0,1) | Details |
| 6329217 | Tredger JM, Smith HM, Davis M, Williams R: Use of a direct high performance liquid chromatography method for multiple hydroxylations in studies of microsomal monooxygenase activities. Biochem Pharmacol. 1984 Jun 1;33(11):1729-36. These changes reflected analogous dissimilar effects of the enzyme inducers on the metabolism of the exogenous cytochrome P-450 substrates aldrin, acetanilide, benzo [alpha] pyrene and ethylmorphine. |
1(0,0,0,1) | Details |