Protein Information

Name ATPases
Synonyms (NA+ + K+)ATPase; ATP1A1; ATPase; ATPase Na+/K+ transporting alpha 1 polypeptide; Na (+) K (+) ATPase; Na (+),K (+) ATPase; Na + K + ATPase; Na K + ATPase…

Compound Information

Name aldrin
CAS

Reference List

PubMed Abstract RScore(About this table)
125084 Desaiah D, Koch RB: Inhibition of fish brain ATPases by aldrin-transdiol, aldrin, dieldrin and photodieldrin. Biochem Biophys Res Commun. 1975 May 5;64(1):13-9.
81(1,1,1,1) Details
6224843 Mehrotra BD, Bansal SK, Desaiah D: Comparative effects of structurally related cyclodiene pesticides on ATPases. J Appl Toxicol. 1982 Dec;2(6):278-83.

Na+-K+-ATPase and oligomycin-insensitive Mg2+-ATPase activities showed a maximum inhibition of 40% at the highest concentration tested for aldrin and telodrin.
34(0,1,1,4) Details
2171528 Chandra M, Poddar MK: In vivo and in vitro effects of aldrin on rat brain synaptosomal Mg2+ and Na+,K (+)-adenosine triphosphatase. Biochem Pharmacol. 1990 Oct 1;40(7):1449-56.

Arrhenius plots of both these ATPases without aldrin under in vivo and in vitro conditions were found to be linear.
18(0,0,3,3) Details
2845111 Kodavanti PR, Mehrotra BD, Chetty SC, Desaiah D: Effect of selected insecticides on rat brain synaptosomal adenylate cyclase and phosphodiesterase. J Toxicol Environ Health. 1988;25(2):207-15.

Previous reports from our laboratory and others clearly indicated that organochlorine insecticides such as chlordecone and DDT are potent inhibitors of ATPases involved in active ion transport.
The present studies were initiated to study the effect of plictran, chlordecone, toxaphene, aldrin, dieldrin, endrin, isodrin, and telodrin on enzymes involved in cyclic AMP metabolism.
2(0,0,0,2) Details