| Name | protein kinase C (protein family or complex) |
|---|---|
| Synonyms | Protein kinase C; PKC |
| Name | lindane |
|---|---|
| CAS | (1α,2α,3β,4α,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7690584 | Carrero I, Rodriguez-Henche N, Guijarro LG, Recio MN, Perez-Albarsanz MA, Prieto JC: Lindane decreases forskolin-stimulated cyclic AMP accumulation but does not modify Gs in rat enterocytes. Cell Signal. 1993 Jul;5(4):453-62. The results on a non-receptor mediated effect of lindane on the adenylate cyclase catalytic subunit itself could be related to: (i) alterations of membrane microdomains surrounding this and other integral proteins which would result in modifications of their activities; and/or (ii) a reciprocal relation between the two main routes of signal transduction so that the activation of protein kinase C (or other Ca (2+)-dependent protein kinases) by lindane would lead to phosphorylation of the adenylate cyclase catalytic subunit.(ABSTRACT TRUNCATED AT 250 WORDS) |
31(0,1,1,1) | Details |
| 7532876 | Criswell KA, Loch-Caruso R, Stuenkel EL: Lindane inhibition of gap junctional communication in myometrial myocytes is partially dependent on phosphoinositide-generated second messengers. Toxicol Appl Pharmacol. 1995 Feb;130(2):280-93. Subsequently, 10 microM lindane was shown to produce a sustained increase in protein kinase C (PKC) activity (31, 17, and 15 pmol of PKC peptide phosphorylated/min/mg protein for 2-, 5-, and 10-min exposures, respectively). |
31(0,1,1,1) | Details |
| 7512927 | Cristofol RM, Rodriguez-Farre E: Hippocampal release is modulated by gamma- and delta-hexachlorocyclohexane isomers: which mechanisms are involved?. Eur J Pharmacol. 1994 Feb 11;252(3):305-12. Likewise, under activation of protein kinase C by phorbol 12,13-dibutyrate (PDB) or inhibition of calmodulin by N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), the stimulatory effect of gamma-hexachlorocyclohexane remained almost unchanged. |
2(0,0,0,2) | Details |
| 16686424 | Mariussen E, Fonnum F: Neurochemical targets and behavioral effects of organohalogen compounds: an update. Crit Rev Toxicol. 2006 Mar;36(3):253-89. For instance, several reports have shown that OHCs alter neurotransmitter functions in CNS and Ca2+ homeostatic processes, induce protein kinase C (PKC) and phospholipase A2 (PLA2) mobilization, and induce oxidative stress. In the 1970s it was discovered that PCBs and some chlorinated pesticides, such as lindane, have potentials after both acute and chronic exposure. |
1(0,0,0,1) | Details |
| 12645305 | Sauviat MP, Pages N: [Cardiotoxicity of lindane, a gamma isomer of hexachlorocyclohexane] . J Soc Biol. 2002;196(4):339-48. TRH modifies the current kinetics of human HERG potassium channel co-expressed in Xenopus oocytes with the TRH receptor, whose activity is modulated via the protein kinase C pathway linked to a G protein-coupled receptor and is regulated by changes in the PIP2 concentration in the membrane. |
1(0,0,0,1) | Details |