Protein Information

Name butyrylcholinesterase
Synonyms Acylcholine acylhydrolase; BCHE; BCHE protein; Butyrylcholine esterase; Butyrylcholinesterase; CHE1; Choline esterase II; Cholinesterase…

Compound Information

Name azamethiphos
CAS

Reference List

PubMed Abstract RScore(About this table)
14580806 Brown M, Davies IM, Moffat CF, Redshaw J, Craft JA: Characterisation of choline esterases and their tissue and subcellular distribution in mussel (Mytilus edulis). Mar Environ Res. 2004 Apr;57(3):155-69.

Inhibition of cholinesterase activity by azamethiphos in gill 'microsomal' fraction gave an IC50 of approximately 100 microM and showed both time and concentration dependence.
85(1,1,1,5) Details
1637204 Fossi MC, Leonzio C, Massi A, Lari L, Casini S: Serum esterase inhibition in birds: a nondestructive biomarker to assess organophosphorus and carbamate contamination. Arch Environ Contam Toxicol. 1992 Jul;23(1):99-104.

In the first treatment, serum butyrylcholinesterase (BChE) and carboxylesterase (CbE) were drastically inhibited in the azamethiphos-treated group, 24 h after the dose.
81(1,1,1,1) Details
1808835 Kohzaki K, Masaoka T, Nagayama M, Akahori F, Sakaguchi K, Kohzaki R: Effects of azamethiphos, an organophosphorus insecticide, on serum cholinesterase activity and isoenzymes in the rat. Vet Hum Toxicol. 1991 Dec;33(6):575-8.

The inhibitory effect of azamethiphos (Az), an organophosphorus insecticide, was detected in both the serum cholinesterase (ChE) activity and the ChE isoenzyme concentration in male Wistar rats.
37(0,1,2,2) Details
17655990 Hannam ML, Hagger JA, Jones MB, Galloway TS: Characterisation of esterases as potential biomarkers of pesticide exposure in the lugworm Arenicola marina (Annelida: Polychaeta). Environ Pollut. 2008 Mar;152(2):342-50. Epub 2007 Jul 25.

Exposure to the organophosphorus pesticide azamethiphos yielded an in vitro IC50 of 5 microg l (-1) for propionylcholinesterase (PChE).
7(0,0,1,2) Details
18177688 Stefano B, Ilaria C, Silvano F: Cholinesterase activities in the scallop Pecten jacobaeus: characterization and effects of exposure to aquatic contaminants. Sci Total Environ. 2008 Mar 15;392(1):99-109. Epub 2008 Jan 3.

The main aims of the present study were: 1) to characterize the biochemical properties of ChEs in tissues of the bivalve Pecten jacobaeus, using different specific substrates and selective inhibitors; 2) to measure sensitivity of ChE activities to in vitro exposure to the OPs azamethiphos and DFP and to the heavy metals cadmium and zinc.
2(0,0,0,2) Details
17324630 Corsi I, Pastore AM, Lodde A, Palmerini E, Castagnolo L, Focardi S: Potential role of cholinesterases in the invasive capacity of the freshwater bivalve, Anodonta woodiana (Bivalvia: Unionacea): a comparative study with the indigenous species of the genus, Anodonta sp. Comp Biochem Physiol C Toxicol Pharmacol. 2007 Apr;145(3):413-9. Epub 2007 Feb 1.

Similar IC (50) of 10 (-5)-10 (-6) M were observed for DFP and azamethiphos in both species.
2(0,0,0,2) Details
16718740 Kristensen M, Huang J, Qiao CL, Jespersen JB: Variation of Musca domestica L. acetylcholinesterase in Danish housefly populations. Pest Manag Sci. 2006 Aug;62(8):738-45.

Anti-cholinesterase resistance is in many cases caused by modified acetylcholinesterase (MACE).
A comparison was made of toxicological data and AChE activity gathered from 21 field populations and nine laboratory strains of houseflies, Musca domestica L., to elucidate the best way of generating data to provide advice for management strategies and gathering information for resistance risk assessment on the organophosphates azamethiphos and dimethoate and the carbamate methomyl, which have been the primary insecticides used against adult houseflies in Denmark.
2(0,0,0,2) Details
17972302 Kristensen M, Jespersen JB: Susceptibility to thiamethoxam of Musca domestica from Danish livestock farms. Pest Manag Sci. 2008 Feb;64(2):126-32.

BACKGROUND: Neonicotinoid baits are currently replacing anticholinesterase baits for control of adult houseflies (Musca domestica L.).
RESULTS: In feeding bioassay with a susceptible strain, thiamethoxam LC (50) at 72 h was 1.7 microg thiamethoxam g (-1) sugar, making it 19-fold, 11-fold and threefold more toxic to houseflies than azamethiphos, methomyl and spinosad respectively.
1(0,0,0,1) Details