Protein Information

Name HCE1
Synonyms CAP1A; HCAP 1; HCAP1; HCE; HCE 1; HCE1; Human capping enzyme 1; RNA Guanylyl Transferase and 5 prime Phosphatase…

Compound Information

Name bioresmethrin
CAS

Reference List

PubMed Abstract RScore(About this table)
16387282 Ross MK, Borazjani A, Edwards CC, Potter PM: Hydrolytic metabolism of pyrethroids by human and other mammalian carboxylesterases. Biochem Pharmacol. 2006 Feb 28;71(5):657-69. Epub 2006 Jan 4.

Pure human CEs (hCE-1 and hCE-2), a rabbit CE (rCE), and two rat CEs (Hydrolases A and B) were used to study the hydrolytic metabolism of the following pyrethroids: 1Rtrans-resmethrin (bioresmethrin), 1RStrans-permethrin, and 1RScis-permethrin. hCE-1 and hCE-2 hydrolyzed trans-permethrin 8- and 28-fold more efficiently than cis-permethrin (when k (cat)/K (m) values were compared), respectively.
33(0,1,1,3) Details
19249324 Yang D, Wang X, Chen YT, Deng R, Yan B: Pyrethroid insecticides: isoform-dependent hydrolysis, induction of cytochrome P450 3A4 and evidence on the involvement of the pregnane X receptor. Toxicol Appl Pharmacol. 2009 May 15;237(1):49-58. Epub 2009 Feb 26.

Some pyrethroids such as bioresmethrin were preferably hydrolyzed by carboxylesterase HCE1, whereas others such as bifenthrin preferably by HCE2.
6(0,0,1,1) Details