Protein Information

Name choline esterase
Synonyms Acylcholine acylhydrolase; BCHE; BCHE protein; Butyrylcholine esterase; Butyrylcholinesterase; CHE1; Choline esterase II; Cholinesterase…

Compound Information

Name ethephon
CAS

Reference List

PubMed Abstract RScore(About this table)
866390 Hennighausen G, Tiefenbach B, Lohs Kh: [The effect of 2-chlorethylphosphonic acid (ethephon) on the activity of cholinesterases in vivo and in vitro with reference to its acute toxicity] Pharmazie. 1977 Mar;32(3):181-2.
6(0,0,1,1) Details
9890196 Sparks SE, Quistad GB, Casida JE: Organophosphorus pesticide-induced butyrylcholinesterase inhibition and potentiation of succinylcholine toxicity in mice. J Biochem Mol Toxicol. 1999;13(2):113-8.

The organophosphorus plant defoliant tribufos (4 h pretreatment, 160 mg/kg) and organophosphorus plant growth regulator ethephon (1 h pretreatment, 200 mg/kg) potentiate the toxicity of succinylcholine by seven- and fourfold, respectively.
5(0,0,0,5) Details
727875 Hennighausen G, Tiefenbach B: [Mechanism of acute toxic effects of chlorocholine chloride and 2-chloroethyl phosphonic acid (Ethephon)]. Arch Exp Veterinarmed. 1978;32(4):609-21.

All the cholinesterases studied, including those obtained from plasma, erythrocytes, and brain from rat and mouse, were inhibited in vitro by approximately identical Etephon concentrations.
1(0,0,0,1) Details
18992204 El-Okazy AM: The Effects of Combination of Gibberellic Acid - 3 (GA3) and Ethephon (2-Chloroethyl Phosphonic Acid) (Plant Growth Regulators) on Some Physiological Parameters in Mice. J Egypt Public Health Assoc. 2008;83(1-2):67-86.

A highly significant dose dependent variation occurred in acetyl choline esterase (AChE) activity among treated groups.
1(0,0,0,1) Details
10898597 Haux JE, Quistad GB, Casida JE: Phosphobutyrylcholinesterase: phosphorylation of the esteratic site of butyrylcholinesterase by ethephon [(2-chloroethyl) phosphonic acid] dianion. Chem Res Toxicol. 2000 Jul;13(7):646-51.
393(4,6,7,8) Details
12482234 Haux JE, Lockridge O, Casida JE: Specificity of ethephon as a butyrylcholinesterase inhibitor and phosphorylating agent. Chem Res Toxicol. 2002 Dec;15(12):1527-33.

Butyrylcholinesterase (BChE) is inhibited by the plant growth regulator (2-chloroethyl) phosphonic acid (ethephon) as observed 25 years ago both in vitro and in vivo in rats and mice and more recently in subchronic studies at low doses with human subjects.
112(1,2,2,2) Details
11886791 Zhang N, Casida JE: Novel irreversible butyrylcholinesterase inhibitors: 2-chloro-1-(substituted-phenyl) ethylphosphonic acids. Bioorg Med Chem. 2002 May;10(5):1281-90.

2-Chloroethylphosphonic acid (ethephon) as the dianion phosphorylates butyrylcholinesterase (BChE) at its active site.
82(1,1,1,2) Details