| Name | CB1 receptor |
|---|---|
| Synonyms | Brain cannabinoid receptor 1; CNR1; CANN 6; CANN6; CB R; CB1; CB1 receptor; CB1A… |
| Name | tribufos |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16243304 | Casida JE, Quistad GB: Serine hydrolase targets of organophosphorus toxicants. Chem Biol Interact. 2005 Dec 15;157-158:277-83. Epub 2005 Oct 21. The toxicological relevance of known secondary OP targets is established mainly from observations with humans (butyrylcholinesterase and neuropathy target esterase-lysophospholipase) and studies with mice (cannabinoid CB1 receptor, carboxylesterase, lysophospholipase and platelet activating factor acetylhydrolase) and hen eggs (arylformamidase or kynurenine formamidase). Pesticides most commonly shown to inhibit these targets in experimental vertebrates are chlorpyrifos and tribufos. |
1(0,0,0,1) | Details |
| 12243867 | Quistad GB, Nomura DK, Sparks SE, Segall Y, Casida JE: Cannabinoid CB1 receptor as a target for chlorpyrifos oxon and other organophosphorus pesticides. Toxicol Lett. 2002 Sep 5;135(1-2):89-93. The plant defoliant tribufos inhibits CB1 in vivo, without cholinergic poisoning signs, by 50% at 50 mg/kg intraperitoneally with a recovery half-time of 3-4 days, indicating covalent derivatization. [3H-ethyl] Chlorpyrifos oxon may be suitable for radiolabeling and characterization of this proposed nucleophilic site. |
85(1,1,1,5) | Details |