Protein Information

Name NR2A
Synonyms GRIN2A; Glutamate [NMDA] receptor subunit epsilon 1; Glutamate [NMDA] receptor subunit epsilon 1 precursor; N methyl D aspartate receptor subtype 2A; N methyl D aspartate receptor subunit 2A; NMDAR2A; NR2A; hNR2A…

Compound Information

Name ACC
CAS 1-aminocyclopropanecarboxylic acid

Reference List

PubMed Abstract RScore(About this table)
19695778 Li TT, Ren WH, Xiao X, Nan J, Cheng LZ, Zhang XH, Zhao ZQ, Zhang YQ: NMDA NR2A and NR2B receptors in the rostral anterior cingulate cortex contribute to pain-related aversion in male rats. Pain. 2009 Nov;146(1-2):183-93. Epub 2009 Aug 19.

4(0,0,0,4) Details
17470281 Wu LJ, Xu H, Ren M, Cao X, Zhuo M: Pharmacological isolation of postsynaptic currents mediated by NR2A- and NR2B-containing NMDA receptors in the anterior cingulate cortex. Mol Pain. 2007 Apr 30;3:11.

3(0,0,0,3) Details
19664265 Toyoda H, Zhao MG, Ulzhofer B, Wu LJ, Xu H, Seeburg PH, Sprengel R, Kuner R, Zhuo M: Roles of the AMPA receptor subunit GluA1 but not GluA2 in synaptic potentiation and activation of ERK in the anterior cingulate cortex. Mol Pain. 2009 Aug 10;5:46.


Glutamate N-methyl D-aspartate (NMDA) receptors in the ACC are critical for the induction of LTP, including both NR2A and NR2B subunits.
1(0,0,0,1) Details
19208366 Fan J, Wu X, Cao Z, Chen S, Owyang C, Li Y: Up-regulation of anterior cingulate cortex NR2B receptors contributes to visceral pain responses in rats. Gastroenterology. 2009 May;136(5):1732-40.e3. Epub 2009 Feb 6.


The NR2A-subtype-receptor antagonist [(R)-[(S)-1-(4-bromo-phenyl)-ethylamino]-(2,3-dioxo-1,2,3,4-tetrahydroquin oxalin-5-yl)-methyl]-phosphonic acid (NVP-AAM077) and the NR2B-receptor-antagonist Ro25-6981 were microinjected into the pACC.
1(0,0,0,1) Details
17522019 Shum FW, Wu LJ, Zhao MG, Toyoda H, Xu H, Ren M, Pinaud R, Ko SW, Lee YS, Kaang BK, Zhuo M: Alteration of cingulate long-term plasticity and behavioral sensitization to inflammation by environmental enrichment. Learn Mem. 2007 Apr 10;14(4):304-12. Print 2007 Apr.


The increased NMDA receptor NR2B/NR2A subunits current ratio is associated with the plasticity seen in the ACC while total protein levels remain unchanged.
1(0,0,0,1) Details