Protein Information

Name MAPK (protein family or complex)
Synonyms MAPK; mitogen activated protein kinase; mitogen activated protein kinases

Compound Information

Name ACC
CAS 1-aminocyclopropanecarboxylic acid

Reference List

PubMed Abstract RScore(About this table)
20106991 Little JP, Safdar A, Cermak N, Tarnopolsky MA, Gibala MJ: Acute endurance exercise increases the nuclear abundance of PGC-1alpha in trained human skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2010 Apr;298(4):R912-7. Epub 2010 Jan 27.


Recent evidence has linked p38 MAPK and AMPK with activation of PGC-1alpha.
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18053155 Toyoda H, Zhao MG, Xu H, Wu LJ, Ren M, Zhuo M: Requirement of extracellular signal-regulated kinase/mitogen-activated protein kinase for long-term potentiation in adult mouse anterior cingulate cortex. Mol Pain. 2007 Dec 1;3:36.

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19729990 Gupta AK, Wilke WW, Taylor EN, Bodeker KL, Hoffman HT, Milhem MM, Buatti JM, Robinson RA: Signaling pathways in adenoid cystic cancers: implications for treatment. Cancer Biol Ther. 2009 Oct;8(20):1947-51. Epub 2009 Oct 22.


Tissues from the last nine ACC patients resected at the University of Iowa were immunohistochemically stained with antibodies for EGFR, phosphorylated (P) Akt, and P-MAPK in order to molecularly characterize these tumors.
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18268539 Liu H, Wang Y, Xu J, Su T, Liu G, Ren D: Ethylene signaling is required for the acceleration of cell death induced by the activation of AtMEK5 in Arabidopsis. Cell Res. 2008 Mar;18(3):422-32.


Mitogen-activated protein kinases (MAPKs) are involved in the regulation of plant growth, development and responses to a wide variety of stimuli.
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19914257 Ceylan-Isik AF, Zhao P, Zhang B, Xiao X, Su G, Ren J: Cardiac overexpression of metallothionein rescues cardiac contractile dysfunction and endoplasmic reticulum stress but not autophagy in sepsis. J Mol Cell Cardiol. 2010 Feb;48(2):367-78. Epub 2009 Nov 13.


Oxidative stress, activation of mitogen-activated protein kinase pathways (ERK, JNK and p38), ER stress, autophagy and inflammatory markers iNOS and TNFalpha were evaluated.
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19356676 Nucera C, Goldfarb M, Hodin R, Parangi S: Role of B-Raf (V600E) in differentiated thyroid cancer and preclinical validation of compounds against B-Raf (V600E). Biochim Biophys Acta. 2009 Apr;1795(2):152-61. Epub 2009 Jan 31.


B-Raf (V600E) genetically arises from a transversion point mutation (valine-to-glutamate substitution at amino acid residue-600, V600E) and leads to over activation of the mitogen-activated protein kinases (MAPK) signaling pathway.
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18586010 Ahn J, Lee H, Kim S, Park J, Ha T: The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways. Biochem Biophys Res Commun. 2008 Sep 5;373(4):545-9. Epub 2008 Jun 27.

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