Protein Information

Name NEFA
Synonyms DNA binding protein NEFA; Gastric cancer antigen Zg4; NEFA; NUCB 2; NUCB2; Nucleobindin 2; Nucleobindin 2 precursor; Gastric cancer antigen Zg4s…

Compound Information

Name ACC
CAS 1-aminocyclopropanecarboxylic acid

Reference List

PubMed Abstract RScore(About this table)
19169664 Coletta DK, Sriwijitkamol A, Wajcberg E, Tantiwong P, Li M, Prentki M, Madiraju M, Jenkinson CP, Cersosimo E, Musi N, Defronzo RA: Pioglitazone stimulates AMP-activated protein kinase signalling and increases the expression of genes involved in adiponectin signalling, mitochondrial function and fat oxidation in human skeletal muscle in vivo: a randomised trial. Diabetologia. 2009 Apr;52(4):723-32. Epub 2009 Jan 24.


We hypothesised that pioglitazone would activate the adenosine 5'-monophosphate-activated protein kinase (AMPK) pathway and increase the expression of genes involved in adiponectin signalling, NEFA oxidation and mitochondrial function in human skeletal muscle.
2(0,0,0,2) Details
17515867 Puglianiello A, Germani D, Antignani S, Tomba GS, Cianfarani S: Changes in the expression of hypothalamic lipid sensing genes in rat model of intrauterine growth retardation (IUGR). Pediatr Res. 2007 Apr;61(4):433-7.


Nonesterified fatty acid (NEFA) serum levels were significantly higher in IUGR pups (p <0.0001).
1(0,0,0,1) Details
20060923 Chen J, Tang X, Zhang Y, Ma H, Zou S: Effects of maternal treatment of dehydroepiandrosterone (DHEA) on serum lipid profile and hepatic lipid metabolism-related gene expression in embryonic chickens. Comp Biochem Physiol B Biochem Mol Biol. 2010 Apr;155(4):380-6. Epub 2010 Jan 10.


DHEA treatment resulted in decreased body weight and increased relative liver weight in both maternal and embryonic chickens, while the concentrations of blood triglyceride (TG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C) and non-esterified fatty acid (NEFA) were significantly lower in the 20mg DHEA/kg group as compared to the control group during embryonic development.
1(0,0,0,1) Details
20094041 Vijayvargia R, Mann K, Weiss HR, Pownall HJ, Ruan H: JNK Deficiency Enhances Fatty Acid Utilization and Diverts Glucose From Oxidation to Glycogen Storage in Cultured Myotubes. Obesity (Silver Spring). 2010 Jan 21.

The increased NEFA utilization was coupled to increased expressions of selective NEFA handling genes including Cd36, Acsl4, and Chka, and enhanced palmitic acid (PA)-dependent suppression of acetyl-CoA carboxylase (Acc).
35(0,1,1,5) Details