Protein Information

Name P16
Synonyms ARF; P19; p14; MTS 1; MTS1; CDK4 inhibitor; CDK4I; CDKN 2…

Compound Information

Name ACC
CAS 1-aminocyclopropanecarboxylic acid

Reference List

PubMed Abstract RScore(About this table)
17912431 Suzuki N, Onda T, Yamamoto N, Katakura A, Mizoe JE, Shibahara T: Mutation of the p16/CDKN2 gene and loss of heterozygosity in malignant mucosal melanoma and adenoid cystic carcinoma of the head and neck. Int J Oncol. 2007 Nov;31(5):1061-7.

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17565817 Zhang CY, Zhou XJ, Zhang ZY, Li J: [DNA methylation in salivary adenoid cystic carcinoma cell lines] . Zhonghua Kou Qiang Yi Xue Za Zhi. 2007 Mar;42(3):135-9.


METHODS: Promoter methylation status of E-cad, p16, RASSF1A, DAPK, and MGMT was determined by methylation-specific polymerase chain reaction (MSP) in ACC cell lines, ACC-2, ACC-3, and ACC-M.
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18326020 Vekony H, Raaphorst FM, Otte AP, van Lohuizen M, Leemans CR, van der Waal I, Bloemena E: High expression of Polycomb group protein EZH2 predicts poor survival in salivary gland adenoid cystic carcinoma. J Clin Pathol. 2008 Jun;61(6):744-9. Epub 2008 Mar 6.


METHODS: Expression of the cell cycle proteins p53, cyclin D1, p16 (INK4a), E2F1 and Ki-67, together with the Polycomb group (PcG) proteins BMI-1, MEL-18, EZH2 and EED was investigated immunohistochemically 21 formalin-fixed, paraffin-embedded primary ACCs in relation to tumour characteristics.
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18332873 Bernheim A, Toujani S, Saulnier P, Robert T, Casiraghi O, Validire P, Temam S, Menard P, Dessen P, Fouret P: High-resolution array comparative genomic hybridization analysis of human bronchial and salivary adenoid cystic carcinoma. Lab Invest. 2008 May;88(5):464-73. Epub 2008 Mar 10.


The minimal common regions of deletions contained the CDKN2A/CDKN2B, TP53, and LIMA1 tumor suppressor genes.
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