Protein Information

Name muscles
Synonyms COX 7a M; COX VIIa M; COX7A; COX7A1; COX7A1 protein; COX7AH; COX7AM; Cytochrome c oxidase subunit 7a H…

Compound Information

Name ACC
CAS 1-aminocyclopropanecarboxylic acid

Reference List

PubMed Abstract RScore(About this table)
18239348 Kim TK, Shimomura Y, Iwanaga K, Katsuura T: Influence of force tremor on mechanomyographic signals recorded with an accelerometer and a condenser microphone during measurement of agonist and antagonist muscles in voluntary submaximal isometric contractions. J Physiol Anthropol. 2008 Jan;27(1):33-42.

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19154959 Koshinaka K, Kawasaki E, Hokari F, Kawanaka K: Effect of acute high-intensity intermittent swimming on post-exercise insulin responsiveness in epitrochlearis muscle of fed rats. Metabolism. 2009 Feb;58(2):246-53.


Maximally insulin-stimulated glucose uptake in skeletal muscle, ie, insulin responsiveness, is reduced in fed animals as compared with fasted animals; but acute prior endurance exercise improves insulin responsiveness in the muscles of fed rats.
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18255222 Janovska A, Hatzinikolas G, Staikopoulos V, McInerney J, Mano M, Wittert GA: AMPK and ACC phosphorylation: effect of leptin, muscle fibre type and obesity. Mol Cell Endocrinol. 2008 Mar 12;284(1-2):1-10. Epub 2008 Jan 3.


We determined the action of leptin on AMPKalpha and ACCbeta phosphorylation and lipid metabolism in soleus (SOL) and extensor digitorum longus (EDL) muscles from lean and obese Wistar rats after 1 and 100 nM leptin.
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19717488 Fuentes T, Ara I, Guadalupe-Grau A, Larsen S, Stallknecht B, Olmedillas H, Santana A, Helge JW, Calbet JA, Guerra B: Leptin receptor 170 kDa (OB-R170) protein expression is reduced in obese human skeletal muscle: a potential mechanism of leptin resistance. Exp Physiol. 2010 Jan;95(1):160-71. Epub 2009 Aug 28.


Skeletal muscle OB-R170 (OB-R long isoform) protein expression was 28 and 25% lower (both P < 0.05) in arm and leg muscles, respectively, of obese men compared with control subjects.
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18187610 Thomson DM, Fick CA, Gordon SE: AMPK activation attenuates S6K1, 4E-BP1, and eEF2 signaling responses to high-frequency electrically stimulated skeletal muscle contractions. J Appl Physiol. 2008 Mar;104(3):625-32. Epub 2008 Jan 10.


Extensor digitorum longus muscles (n = 8/group) were subjected to a 22-min bout of lengthening contractions by high-frequency sciatic nerve electrical stimulation (STIM) in young adult (8 mo) Fischer 344 x Brown Norway male rats.
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18536512 Kim TK, Shimomura Y, Iwanaga K, Katsuura T: Comparison of an accelerometer and a condenser microphone for mechanomyographic signals during measurement of agonist and antagonist muscles in sustained isometric muscle contractions. J Physiol Anthropol. 2008 May;27(3):121-31.

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18059585 Han B, Zhu MJ, Ma C, Du M: Rat hindlimb unloading down-regulates insulin like growth factor-1 signaling and AMP-activated protein kinase, and leads to severe atrophy of the soleus muscle. Appl Physiol Nutr Metab. 2007 Dec;32(6):1115-23.


The objective of this study was to show the effect of hindlimb unloading on IGF-1 signaling and AMP-activated protein kinase (AMPK) activity in rat soleus and extensor digitorum longus (EDL) muscles.
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19395107 Kamimura T, Yoshioka K, Ito S, Kusakabe T: Increased rate of force development of elbow flexors by antagonist conditioning contraction. Hum Mov Sci. 2009 Aug;28(4):407-14. Epub 2009 Apr 22.


The effects of isometric antagonist conditioning contraction (ACC) at various durations and intensities on the contractile force, electromyographic (EMG) amplitude, and their rates of rise of elbow flexor muscles were examined in healthy participants.
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17925454 Thomson DM, Brown JD, Fillmore N, Condon BM, Kim HJ, Barrow JR, Winder WW: LKB1 and the regulation of malonyl-CoA and fatty acid oxidation in muscle. . Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1572-9. Epub 2007 Oct 9.


Likewise, the decrease in malonyl-CoA levels after muscle contraction was attenuated in KO gastrocnemius muscles, suggesting that LKB1 plays an important role in promoting the inhibition of ACC, likely by activation of AMPK.
1(0,0,0,1) Details
19746452 Hanajima R, Terao Y, Nakatani-Enomoto S, Hamada M, Yugeta A, Matsumoto H, Yamamoto T, Tsuji S, Ugawa Y: Postural tremor in X-linked spinal and bulbar muscular atrophy. . Mov Disord. 2009 Oct 30;24(14):2063-9.


For eight patients (36-63 years old) with genetically confirmed SBMA, we recorded surface electromyograms (EMGs) from the forearm muscles and hand movements with an accelerometer (ACC) while maintaining a posture with and without a weight load.
1(0,0,0,1) Details
17762189 Mailloux R, Lemire J, Appanna V: Aluminum-induced mitochondrial dysfunction leads to lipid accumulation in human hepatocytes: a link to obesity. Cell Physiol Biochem. 2007;20(5):627-38.


Mitochondrial dysfunction is the cause of a variety of pathologies associated with high energy-requiring tissues like the brain and muscles.
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17618402 Tubbs RS, Loukas M, Shoja MM, Apaydin N, Oakes WJ, Salter EG: Anatomy and potential clinical significance of the vastoadductor membrane. Surg Radiol Anat. 2007 Oct;29(7):569-73. Epub 2007 Jul 7.


The authors would also hypothesize that due to the interconnection between the adductor magnus and vastus medialis by the vastoadductor membrane that a potential synergy exists between the functions of these two muscles.
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20057367 Anavi S, Ilan E, Tirosh O, Madar Z: Infusion of a Lipid Emulsion Modulates AMPK and Related Proteins in Rat Liver, Muscle, and Adipose Tissues. Obesity (Silver Spring). 2010 Jan 7.


Muscles exposed to LE for 6 days exhibited increased AMPK and acetyl-CoA carboxylase (ACC) phosphorylation, along with a greater association between AMPK and Ca (2+)/calmodulin-dependent protein kinase kinase (CaMKK).
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17682605 Krasny J, Brunnerova R, Syslova J, Ciprychova J, Celedova J, Modlingerova E: [Analysis of movement disorders surgeries at the Department of Ophthalmology, the FNKV Hospital, Prague, Czech Republic, during the ten-years period]. Cesk Slov Oftalmol. 2007 Jul;63(4):249-61.

The solely surgery on oblique or vertical muscles was performed in 16 %, and the most common operative procedure was the retro-position of the lower oblique muscle acc. to Parkes, and on the second place, there was its partial myotomy with electro-cautery acc. to Romer-Martinez.
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19273578 Thomson DM, Brown JD, Fillmore N, Ellsworth SK, Jacobs DL, Winder WW, Fick CA, Gordon SE: AMP-activated protein kinase response to contractions and treatment with the AMPK activator AICAR in young adult and old skeletal muscle. J Physiol. 2009 May 1;587(Pt 9):2077-86. Epub 2009 Mar 9.


Here we tested the hypothesis that AMPK would also be hyperactivated in O vs YA fast-twitch extensor digitorum longus muscles from Fischer (344) x Brown Norway (FBN) rats (n = 8 per group) in response to high-frequency electrical stimulation of the sciatic nerve (HFES) or injection of AICAR, an activator of AMPK.
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