Protein Information

Name cytochrome c
Synonyms CYC; CYCS; Cytochrome C; HCS; Cytochrome Cs

Compound Information

Name ACC
CAS 1-aminocyclopropanecarboxylic acid

Reference List

PubMed Abstract RScore(About this table)
18669938 Branvold DJ, Allred DR, Beckstead DJ, Kim HJ, Fillmore N, Condon BM, Brown JD, Sudweeks SN, Thomson DM, Winder WW: Thyroid hormone effects on LKB1, MO25, phospho-AMPK, phospho-CREB, and PGC-1alpha in rat muscle. J Appl Physiol. 2008 Oct;105(4):1218-27. Epub 2008 Jul 31.


Four proteins having CREB response elements (CRE) in promoter regions of their genes (peroxisome proliferator-activated receptor-gamma coactivator-1alpha, uncoupling protein 3, cytochrome c, and hexokinase II) were all increased in soleus in response to thyroid hormones.
1(0,0,0,1) Details
19589718 Chu WF, Wu DM, Liu W, Wu LJ, Li DZ, Xu DY, Wang XF: Sulforaphane induces G2-M arrest and apoptosis in high metastasis cell line of salivary gland adenoid cystic carcinoma. Oral Oncol. 2009 Nov;45(11):998-1004. Epub 2009 Jul 8.


In terms of apoptosis, SFN increased the expression of Bax and decreased the level of Bcl-2 and subsequently triggered release of cytochrome c from mitochondria and activation of caspase-3, but Fas level and caspase-8 activity remained unchanged at all time points.
1(0,0,0,1) Details
18174272 Rector RS, Thyfault JP, Morris RT, Laye MJ, Borengasser SJ, Booth FW, Ibdah JA: Daily exercise increases hepatic fatty acid oxidation and prevents steatosis in Otsuka Long-Evans Tokushima Fatty rats. Am J Physiol Gastrointest Liver Physiol. 2008 Mar;294(3):G619-26. Epub 2008 Jan 3.


However, fatty acid synthase and acetyl-coenzyme A carboxylase (ACC) content were significantly reduced (approximately 70 and approximately 35%, respectively), and ACC phosphorylation and cytochrome c content were significantly elevated (approximately 35 and approximately 30%, respectively) in the Ex animals.
1(0,0,0,1) Details
17887962 Lawen A: Another piece of the puzzle of apoptotic cytochrome c release. Mol Microbiol. 2007 Nov;66(3):553-6. Epub 2007 Sep 20.

In this issue of Molecular Microbiology, experiments based on yeast genetics analyse the roles of the three proteins commonly considered to form the PTP, i.e. porin, ADP/ATP carrier (ACC) and mitochondrial cyclophilin, on apoptosis-like cell death.
1(0,0,0,1) Details