Protein Information

Name glycogen synthase
Synonyms GSY; GYS; GYS 1; GYS1; GYS1 protein; Glycogen synthase; Glycogen synthase 1; Glycogen synthase 1 (Muscle) variant…

Compound Information

Name ACC
CAS 1-aminocyclopropanecarboxylic acid

Reference List

PubMed Abstract RScore(About this table)
20094041 Vijayvargia R, Mann K, Weiss HR, Pownall HJ, Ruan H: JNK Deficiency Enhances Fatty Acid Utilization and Diverts Glucose From Oxidation to Glycogen Storage in Cultured Myotubes. Obesity (Silver Spring). 2010 Jan 21.

We show for the first time that cellular JNK2- and JNK1/JNK2-deficiency divert glucose from oxidation to glycogenesis due to increased glycogen synthase (GS) activity and induction of Pdk4.
The increased NEFA utilization was coupled to increased expressions of selective NEFA handling genes including Cd36, Acsl4, and Chka, and enhanced palmitic acid (PA)-dependent suppression of acetyl-CoA carboxylase (Acc).
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17935292 Underwood KR, Tong J, Zhu MJ, Shen QW, Means WJ, Ford SP, Paisley SI, Hess BW, Du M: Relationship between kinase phosphorylation, muscle fiber typing, and glycogen accumulation in longissimus muscle of beef cattle with high and low intramuscular fat. J Agric Food Chem. 2007 Nov 14;55(23):9698-703. Epub 2007 Oct 13.


Glycogen synthase kinase 3 (GSK3) down-regulates glycogen synthesis through phosphorylation of glycogen synthase.
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19960007 Zou F, Mao XQ, Wang N, Liu J, Ou-Yang JP: Astragalus polysaccharides alleviates glucose toxicity and restores glucose homeostasis in diabetic states via activation of AMPK. Acta Pharmacol Sin. 2009 Dec;30(12):1607-15.


The expression and activity of skeletal muscle AMPKalpha and acetyl-CoA carboxylase (ACC), and the phosphorylation of hepatic glycogen synthase (GS), the glycogen synthase (GS),were measured by Western blotting.
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